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dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorSpencer, Kevin M.
dc.contributor.authorDickey, Chandlee C.
dc.contributor.authorVoglmaier, Martina M.
dc.contributor.authorSeidman, Larry Joel
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorMcCarley, Robert William
dc.date.accessioned2016-09-23T19:39:04Z
dc.date.issued2009
dc.identifier.citationNiznikiewicz, Margaret A., Kevin M. Spencer, Chandlee Dickey, Martina Voglmaier, Larry J. Seidman, Martha E. Shenton, and Robert W. McCarley. 2009. Abnormal Pitch Mismatch Negativity in Individuals with Schizotypal Personality Disorder. Schizophrenia Research 110, no. 1-3: 188–193. doi:10.1016/j.schres.2008.10.017.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28552531
dc.description.abstractBackground: The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there are also have been reports of reduced duration MMN in first episode schizophrenia patients (Umbricht & Krljes, 2005), with some studies finding no pitch MMN amplitude differences (Salisbury et al., 2002) while others reporting a modest reduction (Umbricht et al., 2006) in recent onset schizophrenia patients. To our knowledge no reports exist of MMN in SPD individuals. Methods: Twenty six normal (14 females) control and 23 SPD (12 females) individuals were tested using the pitch MMN paradigm. Normal control (NC) and SPD individuals were recruited from the general population and assessed using DSM-IV. SPD individuals were included if they met 5 or more criteria for SPD disorder. The subjects listened to 2000 frequent 1 kHz pure tones and 100 rare 1.2 kHz pure tones while reading a magazine article. MMN was measured from a difference waveform within the latency window of 175–276 msec. Results: Reduced MMN amplitude was found in SPD relative to NC subjects (p< 0.045). Conclusions: These results point to potential differences between SPD and schizophrenia, where no reduction in MMN was found in most studies of first episode patients.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2008.10.017en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285443/en_US
dash.licenseLAA
dc.subjectMMNen_US
dc.subjectSPDen_US
dc.subjectschizophreniaen_US
dc.subjectauditory processingen_US
dc.subjectauditory cortexen_US
dc.titleAbnormal pitch mismatch negativity in individuals with schizotypal personality disorderen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-23T19:39:04Z
dc.identifier.doi10.1016/j.schres.2008.10.017*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedSpencer, Kevin
dash.contributor.affiliatedVoglmaier, Martina
dash.contributor.affiliatedDickey, Chandlee
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


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