Show simple item record

dc.contributor.authorPark, Hae-Jeong
dc.contributor.authorWestin, Carl-Fredrik
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorMaier, Stephan Ernst
dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorBaer, Aaron H
dc.contributor.authorFrumin, Melissa
dc.contributor.authorKikinis, Ron
dc.contributor.authorJolesz, Ferenc A.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-27T19:46:17Z
dc.date.issued2004
dc.identifier.citationPark, Hae-Jeong, Carl-Fredrik Westin, Marek Kubicki, Stephan E. Maier, Margaret Niznikiewicz, Aaron Baer, Melissa Frumin, et al. 2004. “White Matter Hemisphere Asymmetries in Healthy Subjects and in Schizophrenia: a Diffusion Tensor MRI Study.” NeuroImage 23 (1) (September): 213–223. doi:10.1016/j.neuroimage.2004.04.036.en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28559578
dc.description.abstractHemisphere asymmetry was explored in normal healthy subjects and in patients with schizophrenia using a novel voxel-based tensor analysis applied to fractional anisotropy (FA) of the diffusion tensor. Our voxel-based approach, which requires precise spatial normalization to remove the misalignment of fiber tracts, includes generating a symmetrical group average template of the diffusion tensor by applying nonlinear elastic warping of the demons algorithm. We then normalized all 32 diffusion tensor MRIs from healthy subjects and 23 from schizophrenic subjects to the symmetrical average template. For each brain, six channels of tensor component images and one T2-weighted image were used for registration to match tensor orientation and shape between images. A statistical evaluation of white matter asymmetry was then conducted on the normalized FA images and their flipped images. In controls, we found left-higher-than-right anisotropic asymmetry in the anterior part of the corpus callosum, cingulum bundle, the optic radiation, and the superior cerebellar peduncle, and right-higher-than-left anisotropic asymmetry in the anterior limb of the internal capsule and the anterior limb’s prefrontal regions, in the uncinate fasciculus, and in the superior longitudinal fasciculus. In patients, the asymmetry was lower, although still present, in the cingulum bundle and the anterior corpus callosum, and not found in the anterior limb of the internal capsule, the uncinate fasciculus, and the superior cerebellar peduncle compared to healthy subjects. These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neuro-developmental abnormalities in schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.neuroimage.2004.04.036en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794419/en_US
dash.licenseLAA
dc.subjecthemisphere asymmetryen_US
dc.subjectdiffusion tensor MRIen_US
dc.subjectfractional anisotropyen_US
dc.titleWhite matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNeuroImageen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-27T19:46:17Z
dc.identifier.doi10.1016/j.neuroimage.2004.04.036*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedBaer, Aaron H
dash.contributor.affiliatedFrumin, Melissa
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedMaier, Stephan
dash.contributor.affiliatedJolesz, Ferenc
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005
dc.identifier.orcid0000-0001-7227-7058


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record