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dc.contributor.authorKasai, Kiyoto
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorSalisbury, Dean F.
dc.contributor.authorOnitsuka, Toshiaki
dc.contributor.authorDemeo, Susan
dc.contributor.authorYurgelun-Todd, Deborah
dc.contributor.authorKikinis, Ron
dc.contributor.authorJolesz, Ferenc A.
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-27T19:50:29Z
dc.date.issued2004
dc.identifier.citationKasai K, McCarley RW, Salisbury DF, Onitsuka T, Demeo S, Yurgelun-Todd D, Kikinis R, Jolesz FA, Shenton ME. 2004. Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study. Schizophr Res 71, no. 1:65-76. doi:10.1016/j.schres.2003.12.010en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28559581
dc.description.abstractA high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical symptoms, and with abnormalities in other limbic structures remains unclear, as does the question of whether a similar abnormality is present in affective psychosis. Seventy-four patients at their first hospitalization, 33 with schizophrenia and 41 with affective (mainly manic) psychosis, and 56 healthy control subjects underwent high-spatial-resolution magnetic resonance imaging (MRI). CSP on six slices or more on 0.9375-mm resampled coronal images was categorized as abnormal. The prevalence of abnormal CSP in both schizophrenic patients (26.1%) and affective psychosis patients (18.2%) was significantly higher than was observed in control subjects (8.2%). In schizophrenic patients only, larger CSP was significantly associated with more severe thinking disturbance and smaller left parahippocampal gyrus gray matter volumes. While the relationships between CSP ratings and clinical symptoms did not significantly differ between the two psychosis groups as assessed by the comparison of regression slopes, the association with limbic volumes appeared to be specific to schizophrenic patients. These results suggest that psychosis associated with schizophrenia and affective disorder share, at least to some extent, neurodevelopmental abnormalities involving midline structures and associated psychopathological consequences. However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2003.12.010en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811876/en_US
dash.licenseLAA
dc.subjectcavum septum pellucidumen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectneurodevelopmenten_US
dc.subjectschizophreniaen_US
dc.subjectaffective disorderen_US
dc.subjectfirst-episodeen_US
dc.titleCavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-27T19:50:29Z
dc.identifier.doi10.1016/j.schres.2003.12.010*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedJolesz, Ferenc
dash.contributor.affiliatedYurgelun-Todd, Deborah
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0001-7227-7058


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