An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis
View/ Open
Author
Wiegand, Laura C.
Hirayasu, Yoshio
Salisbury, Dean F.
Heckers, Stephan
Schwartz, Daniel
Spencer, Magdalena
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1176/appi.ajp.162.1.65Metadata
Show full item recordCitation
Wiegand, Laura C., Simon K. Warfield, James J. Levitt, Yoshio Hirayasu, Dean F. Salisbury, Stephan Heckers, Sylvain Bouix, et al. 2005. An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis. AJP 162, no. 1: 65–70. doi:10.1176/appi.ajp.162.1.65.Abstract
Objective: The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia. Method: An estimate of the surface complexity of the prefrontal cortex was derived from the number of voxels along the boundary between gray matter and CSF. Magnetic resonance imaging scans were acquired from patients with a first episode of schizophrenia (N=17), patients with a first episode of affective psychosis (N=17), and normal comparison subjects (N=17), age-matched within a narrow age range (18–29 years). This study group was the focus of a previous study that showed lower prefrontal cortical volume in patients with schizophrenia. Results: Prefrontal cortical complexity was not significantly different among the groups. However, the schizophrenia patients differed significantly from the normal comparison subjects in asymmetry, with the schizophrenia patients showing less left-greater-than-right asymmetry in cortical complexity than the comparison subjects. Conclusions: An abnormal pattern of asymmetry in the prefrontal cortex of first-episode patients with schizophrenia provides evidence for a neurodevelopmental mechanism in the etiology of schizophrenia.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768063/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:28559585
Collections
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)