Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients
View/ Open
Author
Kuroki, Noriomi
Salisbury, Dean F.
Park, Hae-Jeong
Woolston, Sophie
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1016/j.biopsych.2005.09.021Metadata
Show full item recordCitation
Kuroki, Noriomi, Marek Kubicki, Paul G. Nestor, Dean F. Salisbury, Hae-Jeong Park, James J. Levitt, Sophie Woolston, et al. 2006. “Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients.” Biological Psychiatry 60 (1) (July): 22–31. doi:10.1016/j.biopsych.2005.09.021.Abstract
Background: The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. Methods: Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (Dm), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. Results: FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. Dm was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean Dm and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. Conclusions: These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768597/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:28566444
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)