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dc.contributor.authorKuroki, Noriomi
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorSalisbury, Dean F.
dc.contributor.authorPark, Hae-Jeong
dc.contributor.authorLevitt, James Jonathan
dc.contributor.authorWoolston, Sophie
dc.contributor.authorFrumin, Melissa
dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorWestin, Carl-Fredrik
dc.contributor.authorMaier, Stephan Ernst
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-28T17:59:10Z
dc.date.issued2006
dc.identifier.citationKuroki, Noriomi, Marek Kubicki, Paul G. Nestor, Dean F. Salisbury, Hae-Jeong Park, James J. Levitt, Sophie Woolston, et al. 2006. “Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients.” Biological Psychiatry 60 (1) (July): 22–31. doi:10.1016/j.biopsych.2005.09.021.en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28566444
dc.description.abstractBackground: The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. Methods: Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (Dm), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. Results: FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. Dm was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean Dm and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. Conclusions: These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.biopsych.2005.09.021en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768597/en_US
dash.licenseLAA
dc.subjectanisotropyen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectfornixen_US
dc.subjecthippocampusen_US
dc.subjectMRIen_US
dc.subjectwhite matteren_US
dc.titleFornix Integrity and Hippocampal Volume in Male Schizophrenic Patientsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBiological Psychiatryen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-28T17:59:10Z
dc.identifier.doi10.1016/j.biopsych.2005.09.021*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedFrumin, Melissa
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedMaier, Stephan
dash.contributor.affiliatedLevitt, James
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


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