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dc.contributor.authorDevlin, Maureen
dc.contributor.authorLieberman, Daniel
dc.date.accessioned2009-05-04T14:18:29Z
dc.date.issued2007
dc.identifier.citationDevlin, Maureen and Daniel E. Lieberman. 2007. Complex interactions between estrogen, strain, and exercise-induced periosteal bone growth. Abstracts of AAPA poster and podium presentations. American Journal of Physical Anthropology 131(S44): 99.en
dc.identifier.issn0002-9483en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:2894775
dc.description.abstractUnderstanding the relationship between bone strain and bone growth is critical for interpreting variations in skeletal robusticity. Recently we presented a model for interactions between estrogen, strain, and periosteal bone growth, in which high estrogen (E2) increases, and low (E2) decreases, osteogenic responses to strain. We compared cortical growth in expercised and sedentary sheep (Ovis aries) with higher vs. lower estrogen levels, and showed that exercised animals with high E2 added substantially more bone than those with lower E2. However, without normal controls, it was unclear whether exercise-induced cortical growth was stimulated by high E2, suppressed by lower E2, or both. Here we present a broader test of interactions between E2 levels (normal, low, high) and loading (exercised and sedentary). Low E2 animals were vaccinated against GnRH to suppress estrogen, while high E2 animals received estrogen implants. After 45 days, periosteal bone growth was measured at hindlimb midshafts. The results support the hypothesis that estrogen upregulates strain-induced cortical bone growth: exercised, high-E2 animals grew 6-27% more bone than exercised animals with lower E2 levels, or sedentary animals (p<.05). The effects of the anti-GnRH vaccine on bone growth are more complex. Assays showed that vaccinated animals had normal, not decreased, E2 levels, but grew 34-39% less bone in response to exercise than normal controls (p<.05). This suggests the vaccine affected strain-induced bone growth without changing circulating E2, an unexpected finding. These results demonstrate that variation in E2 levels may produce differential growth response to similar mechanical loading through complex mechanisms.en
dc.description.sponsorshipAnthropologyen
dc.description.sponsorshipHuman Evolutionary Biology
dc.language.isoen_USen
dc.publisherJohn Wiley & Sonsen
dc.relation.isversionofhttp://dx.doi.org/10.1002/ajpa.20577en
dash.licenseLAA
dc.titleComplex Interactions Between Estrogen, Strain, and Exercise-Induced Periosteal Bone Growthen
dc.relation.journalAmerican Journal of Physical Anthropologyen
dash.depositing.authorLieberman, Daniel
dc.identifier.doi10.1002/ajpa.20577*
dash.contributor.affiliatedLieberman, Daniel


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