Electron tomography and immunonanogold electron microscopy for investigating intracellular trafficking and secretion in human eosinophils

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Electron tomography and immunonanogold electron microscopy for investigating intracellular trafficking and secretion in human eosinophils

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Title: Electron tomography and immunonanogold electron microscopy for investigating intracellular trafficking and secretion in human eosinophils
Author: Melo, Rossana C. N.; Dvorak, Ann M.; Weller, Peter Fahey

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Citation: Melo, Rossana C. N., Ann M. Dvorak, and Peter F. Weller. 2008. “Electron Tomography and Immunonanogold Electron Microscopy for Investigating Intracellular Trafficking and Secretion in Human Eosinophils.” Journal of Cellular and Molecular Medicine 12 (4) (April 10): 1416–1419. doi:10.1111/j.1582-4934.2008.00346.x.
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Abstract: Electron tomography (ET) has increasingly been used to understand the complexity of membrane systems and protein-trafficking events. By ET and immunonanogold electron microscopy, we recently defined a route for vesicular transport and release of granule-stored products from within activated human eosinophils, cells specialized in the secretion of numerous cytokines and other proteins during inflammatory responses. Here, we highlight these techniques as important tools to unveil a distinct eosinophil vesicular system and secretory pathway.
Published Version: doi:10.1111/j.1582-4934.2008.00346.x
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28993616
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