Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow

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Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow

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Title: Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow
Author: Yu, Vionnie W.C.; Lymperi, Stefania; Oki, Toshihiko; Jones, Alexandra; Swiatek, Peter; Vasic, Radovan; Ferraro, Francesca; Scadden, David T.

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Citation: Yu, Vionnie W.C., Stefania Lymperi, Toshihiko Oki, Alexandra Jones, Peter Swiatek, Radovan Vasic, Francesca Ferraro, and David T. Scadden. 2016. “Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow.” Stem Cell Reports 7 (2): 220-235. doi:10.1016/j.stemcr.2016.06.009. http://dx.doi.org/10.1016/j.stemcr.2016.06.009.
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Abstract: Summary Bone marrow niches for hematopoietic progenitor cells are not well defined despite their critical role in blood homeostasis. We previously found that cells expressing osteocalcin, a marker of mature osteolineage cells, regulate the production of thymic-seeding T lymphoid progenitors. Here, using a selective cell deletion strategy, we demonstrate that a subset of mesenchymal cells expressing osterix, a marker of bone precursors in the adult, serve to regulate the maturation of early B lymphoid precursors by promoting pro-B to pre-B cell transition through insulin-like growth factor 1 (IGF-1) production. Loss of Osx+ cells or Osx-specific deletion of IGF-1 led to a failure of B cell maturation and the impaired adaptive immune response. These data highlight the notion that bone marrow is a composite of specialized niches formed by pairings of specific mesenchymal cells with parenchymal stem or lineage committed progenitor cells, thereby providing distinctive functional units to regulate hematopoiesis.
Published Version: doi:10.1016/j.stemcr.2016.06.009
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982987/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002452
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