The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives†
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Author
Mathieu, Patrick
Bossé, Yohan
Huggins, Gordon S
Corte, Alessandro Della
Pibarot, Philippe
Michelena, Hector I.
Limongelli, Giuseppe
Boulanger, Marie‐Chloé
Evangelista, Arturo
Bédard, Elisabeth
Citro, Rodolfo
Body, Simon C
Nemer, Mona
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1002/cjp2.21Metadata
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Mathieu, P., Y. Bossé, G. S. Huggins, A. D. Corte, P. Pibarot, H. I. Michelena, G. Limongelli, et al. 2015. “The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives†.” The Journal of Pathology: Clinical Research 1 (4): 195-206. doi:10.1002/cjp2.21. http://dx.doi.org/10.1002/cjp2.21.Abstract
Abstract Bicuspid aortic valve is the most prevalent cardiac valvular malformation. It is associated with a high rate of long‐term morbidity including development of calcific aortic valve disease, aortic regurgitation and concomitant thoracic aortic aneurysm and dissection. Recently, basic and translational studies have identified some key processes involved in the development of bicuspid aortic valve and its morbidity. The development of aortic valve disease and thoracic aortic aneurysm and dissection is the result of complex interactions between genotypes, environmental risk factors and specific haemodynamic conditions created by bicuspid aortic valve anatomy. Herein, we review the pathobiology of bicuspid aortic valve with a special emphasis on translational aspects of these basic findings. Important but unresolved problems in the pathology of bicuspid aortic valve and thoracic aortic aneurysm and dissection are discussed, along with the molecular processes involved.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939890/pdf/Terms of Use
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