dc.contributor.author | Pollack, Todd M | en_US |
dc.contributor.author | Trang, Le Thi Thu | en_US |
dc.contributor.author | Ngo, Long | en_US |
dc.contributor.author | Cuong, Do Duy | en_US |
dc.contributor.author | Thuy, Pham Thanh | en_US |
dc.contributor.author | Colby, Donn J | en_US |
dc.date.accessioned | 2016-10-11T20:26:52Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Pollack, Todd M, Le Thi Thu Trang, Long Ngo, Do Duy Cuong, Pham Thanh Thuy, and Donn J Colby. 2016. “Response to hepatitis B vaccination among HIV-infected adults in Vietnam.” Journal of Virus Eradication 2 (2): 102-106. | en |
dc.identifier.issn | 2055-6640 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002557 | |
dc.description.abstract | Abstract Objectives: We sought to determine the rate of response to hepatitis B (HBV) vaccination among HIV-infected adults in Vietnam. Methods: We retrospectively abstracted data from a cohort of HIV-infected adults who had received HBV vaccine at an HIV clinic in Hanoi. We examined demographic, clinical and laboratory factors for associations with development of a protective antibody (Ab) response following vaccination (defined as ‘responders’ with anti-HBs >10 IU/L). Results: Out of 302 HIV-infected patients who completed the vaccine series and follow-up serology testing, 189 (62.6%) had a positive protective Ab response. Female patients had a higher response rate compared to male patients (71.4% vs 56.8%, P=0.01). Among responders, mean CD4 T cell count was 309 cells/μL as compared to 204 cells/μL in non-responders (P<0.0001). On multivariable analysis, CD4 T cell count prior to vaccination was the only factor independently associated with a positive Ab response. Compared to patients with a count less than 100 cells/μL, those with a CD4 T cell count between 100 and 200 cells/μL were 20% more likely to be responders (relative risk [RR] 1.20, 95% confidence interval [CI] 0.77–1.87), those with a CD4 T cell count between 200 and 300 cells/μL were 61% more likely to be responders (RR 1.61, 95% CI 1.05–2.45), and those with a CD4 T cell count greater than 300 cells/μL were 89% more likely to be responders (RR 1.89, 95% CI 1.26–2.83). Conclusions: We found that the CD4 T cell count at the time of vaccination to be the sole predictor of response to HBV vaccination among HIV-infected Vietnamese adults. Our findings highlight the importance of vaccinating HIV-infected adults prior to advanced immunosuppression. | en |
dc.language.iso | en_US | en |
dc.publisher | Mediscript Ltd | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965239/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | HIV | en |
dc.subject | human immunodeficiency virus | en |
dc.subject | Vietnam | en |
dc.subject | hepatitis B | en |
dc.subject | vaccination | en |
dc.subject | CD4 | en |
dc.title | Response to hepatitis B vaccination among HIV-infected adults in Vietnam | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Journal of Virus Eradication | en |
dash.depositing.author | Pollack, Todd M | en_US |
dc.date.available | 2016-10-11T20:26:52Z | |
dash.contributor.affiliated | Pollack, Todd | |
dash.contributor.affiliated | Ngo, Long | |