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dc.contributor.authorLiu, Wei-huien_US
dc.contributor.authorRen, Li-naen_US
dc.contributor.authorWang, Taoen_US
dc.contributor.authorNavarro-Alvarez, Naluen_US
dc.contributor.authorTang, Li-junen_US
dc.date.accessioned2016-10-11T20:26:57Z
dc.date.issued2016en_US
dc.identifier.citationLiu, Wei-hui, Li-na Ren, Tao Wang, Nalu Navarro-Alvarez, and Li-jun Tang. 2016. “The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration.” International Journal of Biological Sciences 12 (8): 954-963. doi:10.7150/ijbs.15715. http://dx.doi.org/10.7150/ijbs.15715.en
dc.identifier.issn1449-2288en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29002569
dc.description.abstractLiver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. LSPCs in the developing liver have been extensively characterized, however, their contributing role to liver regeneration has not been completely understood. In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration. To conclude, liver regeneration can be mainly divided into three distinct restoring levels according to the cause and severity of injury: hepatocyte dominant regeneration, LSPCs mediated regeneration, extrahepatic stem cells participative regeneration. In this review, we focus on the recent findings of liver regeneration, especially on those related to stem/progenitor cells (SPCs)-mediated regeneration and their potential clinical applications and challenges.en
dc.language.isoen_USen
dc.publisherIvyspring International Publisheren
dc.relation.isversionofdoi:10.7150/ijbs.15715en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971734/pdf/en
dash.licenseLAAen_US
dc.subjectliver stem/progenitor cells (LSPCs)en
dc.subjectsinusoidal endothelial progenitor cells (SEPCs)en
dc.subjectmesenchymal stem cells (MSCs)en
dc.subjecthematopoietic stem cells (HSCs)en
dc.subjectliver regenerationen
dc.titleThe Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regenerationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalInternational Journal of Biological Sciencesen
dash.depositing.authorNavarro-Alvarez, Naluen_US
dc.date.available2016-10-11T20:26:57Z
dc.identifier.doi10.7150/ijbs.15715*
dash.contributor.affiliatedNavarro-Alvarez, Nalu


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