The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration

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The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration

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dc.contributor.author Liu, Wei-hui en_US
dc.contributor.author Ren, Li-na en_US
dc.contributor.author Wang, Tao en_US
dc.contributor.author Navarro-Alvarez, Nalu en_US
dc.contributor.author Tang, Li-jun en_US
dc.date.accessioned 2016-10-11T20:26:57Z
dc.date.issued 2016 en_US
dc.identifier.citation Liu, Wei-hui, Li-na Ren, Tao Wang, Nalu Navarro-Alvarez, and Li-jun Tang. 2016. “The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration.” International Journal of Biological Sciences 12 (8): 954-963. doi:10.7150/ijbs.15715. http://dx.doi.org/10.7150/ijbs.15715. en
dc.identifier.issn 1449-2288 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002569
dc.description.abstract Liver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. LSPCs in the developing liver have been extensively characterized, however, their contributing role to liver regeneration has not been completely understood. In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration. To conclude, liver regeneration can be mainly divided into three distinct restoring levels according to the cause and severity of injury: hepatocyte dominant regeneration, LSPCs mediated regeneration, extrahepatic stem cells participative regeneration. In this review, we focus on the recent findings of liver regeneration, especially on those related to stem/progenitor cells (SPCs)-mediated regeneration and their potential clinical applications and challenges. en
dc.language.iso en_US en
dc.publisher Ivyspring International Publisher en
dc.relation.isversionof doi:10.7150/ijbs.15715 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971734/pdf/ en
dash.license LAA en_US
dc.subject liver stem/progenitor cells (LSPCs) en
dc.subject sinusoidal endothelial progenitor cells (SEPCs) en
dc.subject mesenchymal stem cells (MSCs) en
dc.subject hematopoietic stem cells (HSCs) en
dc.subject liver regeneration en
dc.title The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal International Journal of Biological Sciences en
dash.depositing.author Navarro-Alvarez, Nalu en_US
dc.date.available 2016-10-11T20:26:57Z

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