Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates

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Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates

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Title: Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates
Author: Cantley, Alexandra M.; Woznica, Arielle; Beemelmanns, Christine; King, Nicole; Clardy, Jon

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Citation: Cantley, Alexandra M., Arielle Woznica, Christine Beemelmanns, Nicole King, and Jon Clardy. 2016. “Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.” Journal of the American Chemical Society 138 (13): 4326-4329. doi:10.1021/jacs.6b01190. http://dx.doi.org/10.1021/jacs.6b01190.
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Abstract: The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for understanding how multicellularity evolved in the animal lineage. Previously our laboratories isolated and synthesized a bacterially produced sulfonolipid that induces S. rosetta to form multicellular “rosettes.” In this study, we report the identification of a bacterially produced inhibitor of rosettes (IOR-1) as well as the total synthesis of this molecule and all of its stereoisomers. Our results confirm the previously noted specificity and potency of rosette-modulating molecules, expand our understanding of the complex chemical ecology between choanoflagellates and rosette-inducing bacteria, and provide a synthetic probe template for conducting further mechanistic studies on the emergence of multicellularity.
Published Version: doi:10.1021/jacs.6b01190
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968929/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002628
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