dc.contributor.author | Cantley, Alexandra M. | en_US |
dc.contributor.author | Woznica, Arielle | en_US |
dc.contributor.author | Beemelmanns, Christine | en_US |
dc.contributor.author | King, Nicole | en_US |
dc.contributor.author | Clardy, Jon | en_US |
dc.date.accessioned | 2016-10-11T20:27:29Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Cantley, Alexandra M., Arielle Woznica, Christine Beemelmanns, Nicole King, and Jon Clardy. 2016. “Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.” Journal of the American Chemical Society 138 (13): 4326-4329. doi:10.1021/jacs.6b01190. http://dx.doi.org/10.1021/jacs.6b01190. | en |
dc.identifier.issn | 0002-7863 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002628 | |
dc.description.abstract | The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for understanding how multicellularity evolved in the animal lineage. Previously our laboratories isolated and synthesized a bacterially produced sulfonolipid that induces S. rosetta to form multicellular “rosettes.” In this study, we report the identification of a bacterially produced inhibitor of rosettes (IOR-1) as well as the total synthesis of this molecule and all of its stereoisomers. Our results confirm the previously noted specificity and potency of rosette-modulating molecules, expand our understanding of the complex chemical ecology between choanoflagellates and rosette-inducing bacteria, and provide a synthetic probe template for conducting further mechanistic studies on the emergence of multicellularity. | en |
dc.language.iso | en_US | en |
dc.publisher | American Chemical
Society | en |
dc.relation.isversionof | doi:10.1021/jacs.6b01190 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968929/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Journal of the American Chemical Society | en |
dash.depositing.author | Cantley, Alexandra M. | en_US |
dc.date.available | 2016-10-11T20:27:29Z | |
dc.identifier.doi | 10.1021/jacs.6b01190 | * |
dash.contributor.affiliated | Cantley, Alexandra Masu | |
dash.contributor.affiliated | Clardy, Jon | |