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dc.contributor.authorBandopadhayay, Pratitien_US
dc.contributor.authorRamkissoon, Lori A.en_US
dc.contributor.authorJain, Payalen_US
dc.contributor.authorBergthold, Guillaumeen_US
dc.contributor.authorWala, Jeremiahen_US
dc.contributor.authorZeid, Rhamyen_US
dc.contributor.authorSchumacher, Steven E.en_US
dc.contributor.authorUrbanski, Lauraen_US
dc.contributor.authorO’Rourke, Ryanen_US
dc.contributor.authorGibson, William J.en_US
dc.contributor.authorPelton, Kristineen_US
dc.contributor.authorRamkissoon, Shakti H.en_US
dc.contributor.authorHan, Harry J.en_US
dc.contributor.authorZhu, Yuankunen_US
dc.contributor.authorChoudhari, Namrataen_US
dc.contributor.authorSilva, Amandaen_US
dc.contributor.authorBoucher, Katieen_US
dc.contributor.authorHenn, Rosemary E.en_US
dc.contributor.authorKang, Yun Jeeen_US
dc.contributor.authorKnoff, Daviden_US
dc.contributor.authorPaolella, Brenton R.en_US
dc.contributor.authorGladden-Young, Adrianneen_US
dc.contributor.authorVarlet, Pascaleen_US
dc.contributor.authorPages, Melanieen_US
dc.contributor.authorHorowitz, Peleg M.en_US
dc.contributor.authorFederation, Alexanderen_US
dc.contributor.authorMalkin, Hayleyen_US
dc.contributor.authorTracy, Adamen_US
dc.contributor.authorSeepo, Saraen_US
dc.contributor.authorDucar, Matthewen_US
dc.contributor.authorHummelen, Paul Vanen_US
dc.contributor.authorSanti, Mariaritaen_US
dc.contributor.authorBuccoliero, Anna Mariaen_US
dc.contributor.authorScagnet, Mirkoen_US
dc.contributor.authorBowers, Daniel C.en_US
dc.contributor.authorGiannini, Caterinaen_US
dc.contributor.authorPuget, Stephanieen_US
dc.contributor.authorHawkins, Cynthiaen_US
dc.contributor.authorTabori, Urien_US
dc.contributor.authorKlekner, Almosen_US
dc.contributor.authorBognar, Laszloen_US
dc.contributor.authorBurger, Peter C.en_US
dc.contributor.authorEberhart, Charlesen_US
dc.contributor.authorRodriguez, Fausto J.en_US
dc.contributor.authorHill, D. Ashleyen_US
dc.contributor.authorMueller, Sabineen_US
dc.contributor.authorHaas-Kogan, Daphne A.en_US
dc.contributor.authorPhillips, Joanna J.en_US
dc.contributor.authorSantagata, Sandroen_US
dc.contributor.authorStiles, Charles D.en_US
dc.contributor.authorBradner, James E.en_US
dc.contributor.authorJabado, Nadaen_US
dc.contributor.authorGoren, Alonen_US
dc.contributor.authorGrill, Jacquesen_US
dc.contributor.authorLigon, Azra H.en_US
dc.contributor.authorGoumnerova, Lilianaen_US
dc.contributor.authorWaanders, Angela J.en_US
dc.contributor.authorStorm, Phillip B.en_US
dc.contributor.authorKieran, Mark W.en_US
dc.contributor.authorLigon, Keith L.en_US
dc.contributor.authorBeroukhim, Rameenen_US
dc.contributor.authorResnick, Adam C.en_US
dc.date.accessioned2016-10-11T20:27:33Z
dc.date.issued2016en_US
dc.identifier.citationBandopadhayay, P., L. A. Ramkissoon, P. Jain, G. Bergthold, J. Wala, R. Zeid, S. E. Schumacher, et al. 2016. “MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism.” Nature genetics 48 (3): 273-282. doi:10.1038/ng.3500. http://dx.doi.org/10.1038/ng.3500.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29002633
dc.description.abstractAngiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs including 19 Angiocentric Gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in Angiocentric Gliomas. In vitro and in vivo functional studies show MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression, and hemizygous loss of the tumor suppressor QKI. This represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.3500en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767685/pdf/en
dash.licenseLAAen_US
dc.titleMYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanismen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorBandopadhayay, Pratitien_US
dc.date.available2016-10-11T20:27:33Z
dc.identifier.doi10.1038/ng.3500*
dash.authorsorderedfalse
dash.contributor.affiliatedWala, Jeremiah
dash.contributor.affiliatedHaas-Kogan, Daphne
dash.contributor.affiliatedBandopadhayay, Pratiti
dash.contributor.affiliatedPaolella, Brenton R.
dash.contributor.affiliatedGibson, William
dash.contributor.affiliatedSantagata, Sandro
dash.contributor.affiliatedKieran, Mark W.
dash.contributor.affiliatedGoumnerova, Liliana
dash.contributor.affiliatedLigon, Azra
dash.contributor.affiliatedBeroukhim, Rameen
dash.contributor.affiliatedLigon, Keith
dash.contributor.affiliatedBradner, James E


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