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dc.contributor.authorDhana, Klodianen_US
dc.contributor.authorNano, Janaen_US
dc.contributor.authorLigthart, Symenen_US
dc.contributor.authorPeeters, Annaen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorNusselder, Wilmaen_US
dc.contributor.authorDehghan, Abbasen_US
dc.contributor.authorFranco, Oscar H.en_US
dc.date.accessioned2016-10-11T20:27:42Z
dc.date.issued2016en_US
dc.identifier.citationDhana, Klodian, Jana Nano, Symen Ligthart, Anna Peeters, Albert Hofman, Wilma Nusselder, Abbas Dehghan, and Oscar H. Franco. 2016. “Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study.” PLoS Medicine 13 (7): e1002086. doi:10.1371/journal.pmed.1002086. http://dx.doi.org/10.1371/journal.pmed.1002086.en
dc.identifier.issn1549-1277en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29002639
dc.description.abstractBackground: Overweight and obesity are associated with increased risk of type 2 diabetes. Limited evidence exists regarding the effect of excess weight on years lived with and without diabetes. We aimed to determine the association of overweight and obesity with the number of years lived with and without diabetes in a middle-aged and elderly population. Methods and Findings: The study included 6,499 individuals (3,656 women) aged 55 y and older from the population-based Rotterdam Study. We developed a multistate life table to calculate life expectancy for individuals who were normal weight, overweight, and obese and the difference in years lived with and without diabetes. For life table calculations, we used prevalence, incidence rate, and hazard ratios (HRs) for three transitions (healthy to diabetes, healthy to death, and diabetes to death), stratifying by body mass index (BMI) at baseline and adjusting for confounders. During a median follow-up of 11.1 y, we observed 697 incident diabetes events and 2,192 overall deaths. Obesity was associated with an increased risk of developing diabetes (HR: 2.13 [p < 0.001] for men and 3.54 [p < 0.001] for women). Overweight and obesity were not associated with mortality in men and women with or without diabetes. Total life expectancy remained unaffected by overweight and obesity. Nevertheless, men with obesity aged 55 y and older lived 2.8 (95% CI −6.1 to −0.1) fewer y without diabetes than normal weight individuals, whereas, for women, the difference between obese and normal weight counterparts was 4.7 (95% CI −9.0 to −0.6) y. Men and women with obesity lived 2.8 (95% CI 0.6 to 6.2) and 5.3 (95% CI 1.6 to 9.3) y longer with diabetes, respectively, compared to their normal weight counterparts. Since the implications of these findings could be limited to middle-aged and older white European populations, our results need confirmation in other populations. Conclusions: Obesity in the middle aged and elderly is associated with a reduction in the number of years lived free of diabetes and an increase in the number of years lived with diabetes. Those extra years lived with morbidity might place a high toll on individuals and health care systems.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pmed.1002086en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951120/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectEndocrinologyen
dc.subjectEndocrine Disordersen
dc.subjectDiabetes Mellitusen
dc.subjectMetabolic Disordersen
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectObesityen
dc.subjectPeople and Placesen
dc.subjectDemographyen
dc.subjectLife Expectancyen
dc.subjectPublic and Occupational Healthen
dc.subjectBody Mass Indexen
dc.subjectCardiovascular Medicineen
dc.subjectCardiovascular Diseasesen
dc.subjectPulmonologyen
dc.subjectChronic Obstructive Pulmonary Diseaseen
dc.subjectBehavioren
dc.subjectHabitsen
dc.subjectSmoking Habitsen
dc.subjectPhysical Activityen
dc.titleObesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Medicineen
dash.depositing.authorHofman, Alberten_US
dc.date.available2016-10-11T20:27:42Z
dc.identifier.doi10.1371/journal.pmed.1002086*
dash.contributor.affiliatedHofman, Albert
dc.identifier.orcid0000-0002-9865-121X


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