A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

 
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Cronican, James J.
Beier, Kevin T.
Davis, Tina N.
Tseng, Jen-Chieh
Li, Weida
Thompson, David B.
Shih, Allen F.
May, Erin M.
Cepko, Constance L.
Kung, Andrew L.
Zhou, Qiao
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1016/j.chembiol.2011.07.003
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Citation
Cronican, James J., Kevin T. Beier, Tina N. Davis, Jen-Chieh Tseng, Weida Li, David B. Thompson, Allen F. Shih, et al. 2011. “A Class of Human Proteins That Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo.” Chemistry & Biology 18 (7) (July): 833–838. doi:10.1016/j.chembiol.2011.07.003.
Abstract
We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.
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This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:29003557

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