A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

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A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

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Title: A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo
Author: Cronican, James J.; Beier, Kevin T.; Davis, Tina N.; Tseng, Jen-Chieh; Li, Weida; Thompson, David B.; Shih, Allen F.; May, Erin M.; Cepko, Constance L.; Kung, Andrew L.; Zhou, Qiao; Liu, David Ruchien

Note: Order does not necessarily reflect citation order of authors.

Citation: Cronican, James J., Kevin T. Beier, Tina N. Davis, Jen-Chieh Tseng, Weida Li, David B. Thompson, Allen F. Shih, et al. 2011. “A Class of Human Proteins That Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo.” Chemistry & Biology 18 (7) (July): 833–838. doi:10.1016/j.chembiol.2011.07.003.
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Abstract: We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.
Published Version: doi:10.1016/j.chembiol.2011.07.003
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29003557
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