ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation
Wang, Andrew Z
Gu, Frank X
Radovic-Moreno, Aleksandar F
Bander, Neil H
MetadataShow full item record
CitationWang, Andrew Z, Kai Yuet, Liangfang Zhang, Frank X Gu, Minh Huynh-Le, Aleksandar F Radovic-Moreno, Philip W Kantoff, Neil H Bander, Robert Langer, and Omid C Farokhzad. 2010. “ChemoRad Nanoparticles: a Novel Multifunctional Nanoparticle Platform for Targeted Delivery of Concurrent Chemoradiation.” Nanomedicine 5 (3) (April): 361–368. doi:10.2217/nnm.10.6.
AbstractAim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. In this study, we report the development of a novel NP (nanoparticle) therapeutic, ChemoRad NP, which can deliver biologically targeted chemoradiation.
Method: A biodegradable and biocompatible lipid–polymer hybrid NP that is capable of delivering both chemotherapy and radiotherapy was formulated.
Results: Using docetaxel, indium111 and yttrium90 as model drugs, we demonstrated that the ChemoRad NP can encapsulate chemotherapeutics (up to 9% of NP weight) and radiotherapeutics (100 mCi of radioisotope per gram of NP) efficiently and deliver both effectively. Using prostate cancer as a disease model, we demonstrated the targeted delivery of ChemoRad NPs and the higher therapeutic efficacy of ChemoRad NPs.
Conclusion: We believe that the ChemoRad NP represents a new class of therapeutics that holds great potential to improve cancer treatment.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29005178
- HMS Scholarly Articles