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dc.contributor.authorWang, Andrew Z
dc.contributor.authorYuet, Kai
dc.contributor.authorZhang, Liangfang
dc.contributor.authorGu, Frank X
dc.contributor.authorHuynh-Le, Minh
dc.contributor.authorRadovic-Moreno, Aleksandar F
dc.contributor.authorKantoff, Philip Wayne
dc.contributor.authorBander, Neil H
dc.contributor.authorLanger, Robert S.
dc.contributor.authorFarokhzad, Omid Cameron
dc.date.accessioned2016-10-13T20:16:12Z
dc.date.issued2010
dc.identifier.citationWang, Andrew Z, Kai Yuet, Liangfang Zhang, Frank X Gu, Minh Huynh-Le, Aleksandar F Radovic-Moreno, Philip W Kantoff, Neil H Bander, Robert Langer, and Omid C Farokhzad. 2010. “ChemoRad Nanoparticles: a Novel Multifunctional Nanoparticle Platform for Targeted Delivery of Concurrent Chemoradiation.” Nanomedicine 5 (3) (April): 361–368. doi:10.2217/nnm.10.6.en_US
dc.identifier.issn1743-5889en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29005178
dc.description.abstractAim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. In this study, we report the development of a novel NP (nanoparticle) therapeutic, ChemoRad NP, which can deliver biologically targeted chemoradiation. Method: A biodegradable and biocompatible lipid–polymer hybrid NP that is capable of delivering both chemotherapy and radiotherapy was formulated. Results: Using docetaxel, indium111 and yttrium90 as model drugs, we demonstrated that the ChemoRad NP can encapsulate chemotherapeutics (up to 9% of NP weight) and radiotherapeutics (100 mCi of radioisotope per gram of NP) efficiently and deliver both effectively. Using prostate cancer as a disease model, we demonstrated the targeted delivery of ChemoRad NPs and the higher therapeutic efficacy of ChemoRad NPs. Conclusion: We believe that the ChemoRad NP represents a new class of therapeutics that holds great potential to improve cancer treatment.en_US
dc.language.isoen_USen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.isversionofdoi:10.2217/nnm.10.6en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901911/en_US
dash.licenseLAA
dc.subjectBiologically Targeted Nanoparticleen_US
dc.subjectChemoRad NPen_US
dc.subjectChemoradiationen_US
dc.subjectChemoradiation Nanoparticleen_US
dc.subjectNanomedicineen_US
dc.subjectNanotechnologyen_US
dc.subjectProstate Canceren_US
dc.titleChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiationen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNanomedicineen_US
dash.depositing.authorFarokhzad, Omid Cameron
dc.date.available2016-10-13T20:16:12Z
dc.identifier.doi10.2217/nnm.10.6*
dash.contributor.affiliatedKantoff, Philip
dash.contributor.affiliatedLanger, Robert
dash.contributor.affiliatedFarokhzad, Omid


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