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dc.contributor.authorShaw, Leslee J.
dc.contributor.authorBerman, Daniel S.
dc.contributor.authorPicard, Michael Howard
dc.contributor.authorFriedrich, Matthias G.
dc.contributor.authorKwong, Raymond Yan-Kit
dc.contributor.authorStone, Gregg W.
dc.contributor.authorSenior, Roxy
dc.contributor.authorMin, James K.
dc.contributor.authorHachamovitch, Rory
dc.contributor.authorScherrer-Crosbie, Marielle
dc.contributor.authorMieres, Jennifer H.
dc.contributor.authorMarwick, Thomas H.
dc.contributor.authorPhillips, Lawrence M.
dc.contributor.authorChaudhry, Farooq A.
dc.contributor.authorPellikka, Patricia A.
dc.contributor.authorSlomka, Piotr
dc.contributor.authorArai, Andrew E.
dc.contributor.authorIskandrian, Ami E.
dc.contributor.authorBateman, Timothy M.
dc.contributor.authorHeller, Gary V.
dc.contributor.authorMiller, Todd D.
dc.contributor.authorNagel, Eike
dc.contributor.authorGoyal, Abhinav
dc.contributor.authorBorges-Neto, Salvador
dc.contributor.authorBoden, William E.
dc.contributor.authorReynolds, Harmony R.
dc.contributor.authorHochman, Judith S.
dc.contributor.authorMaron, David J.
dc.contributor.authorDouglas, Pamela S.
dc.date.accessioned2016-10-19T19:12:07Z
dc.date.issued2014
dc.identifier.citationShaw, Leslee J., Daniel S. Berman, Michael H. Picard, Matthias G. Friedrich, Raymond Y. Kwong, Gregg W. Stone, Roxy Senior, et al. 2014. “Comparative Definitions for Moderate-Severe Ischemia in Stress Nuclear, Echocardiography, and Magnetic Resonance Imaging.” JACC: Cardiovascular Imaging 7 (6) (June): 593–604. doi:10.1016/j.jcmg.2013.10.021.en_US
dc.identifier.issn1936-878Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29048900
dc.description.abstractThe lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary artery disease (CAD) death or myocardial infarction (MI) associated with ≥10% ischemic myocardium on stress nuclear imaging as the risk threshold for stress echocardiography and cardiac magnetic resonance. A narrative review revealed that ≥10% ischemic myocardium on stress nuclear imaging was associated with a median rate of CAD death or MI of 4.9%/year (interquartile range: 3.75% to 5.3%). For stress echocardiography, ≥3 newly dysfunctional segments portend a median rate of CAD death or MI of 4.5%/year (interquartile range: 3.8% to 5.9%). Although imprecisely delineated, moderate-severe ischemia on cardiac magnetic resonance may be indicated by ≥4 of 32 stress perfusion defects or ≥3 dobutamine-induced dysfunctional segments. Risk-based thresholds can define equivalent amounts of ischemia across the stress imaging modalities, which will help to translate a common understanding of patient risk on which to guide subsequent management decisions.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.jcmg.2013.10.021en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128344/en_US
dash.licenseLAA
dc.subjectcardiac imagingen_US
dc.subjectischemiaen_US
dc.subjectprognosisen_US
dc.titleComparative Definitions for Moderate-Severe Ischemia in Stress Nuclear, Echocardiography, and Magnetic Resonance Imagingen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJACC: Cardiovascular Imagingen_US
dash.depositing.authorPicard, Michael Howard
dc.date.available2016-10-19T19:12:07Z
dc.identifier.doi10.1016/j.jcmg.2013.10.021*
dash.authorsorderedfalse
dash.contributor.affiliatedKwong, Raymond
dash.contributor.affiliatedScherrer-Crosbie, Marielle
dash.contributor.affiliatedPicard, Michael


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