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dc.contributor.authorShi, Jinjun
dc.contributor.authorXu, Yingjie
dc.contributor.authorXu, Xiaoyang
dc.contributor.authorZhu, Xi
dc.contributor.authorPridgen, Eric
dc.contributor.authorWu, Jun
dc.contributor.authorVotruba, Alexander R.
dc.contributor.authorSwami, Archana
dc.contributor.authorZetter, Bruce Robert
dc.contributor.authorFarokhzad, Omid Cameron
dc.date.accessioned2016-10-20T20:28:44Z
dc.date.issued2014
dc.identifier.citationShi, Jinjun, Yingjie Xu, Xiaoyang Xu, Xi Zhu, Eric Pridgen, Jun Wu, Alexander R. Votruba, Archana Swami, Bruce R. Zetter, and Omid C. Farokhzad. 2014. “Hybrid Lipid–polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing.” Nanomedicine: Nanotechnology, Biology and Medicine 10 (5) (July): e897–e900. doi:10.1016/j.nano.2014.03.006.en_US
dc.identifier.issn1549-9634en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29058537
dc.description.abstractThe development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) for sustained, long-term gene silencing. Herein, we present a NP platform with sustained siRNA-release properties, which can be self-assembled using biodegradable and biocompatible polymers and lipids. The hybrid lipid-polymer NPs showed excellent silencing efficacy, and the temporal release of siRNA from the NPs continued for over one month. When tested on luciferase-expressed HeLa cells and A549 lung carcinoma cells after short-term transfection, the siRNA NPs showed greater sustained silencing activity than lipofectamine 2000-siRNA complexes. More importantly, the NP-mediated sustained silencing of prohibitin 1 (PHB1) generates more effective tumor cell growth inhibition in vitro and in vivo than the lipofectamine complexes. We expect that this sustained-release siRNA NP platform could be of interest in both fundamental biological studies and clinical applications.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.nano.2014.03.006en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077924/en_US
dash.licenseOAP
dc.subjectLipid-polymer nanoparticleen_US
dc.titleHybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencingen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNanomedicine: Nanotechnology, Biology and Medicineen_US
dash.depositing.authorFarokhzad, Omid Cameron
dc.date.available2016-10-20T20:28:44Z
dc.identifier.doi10.1016/j.nano.2014.03.006*
dash.authorsorderedfalse
dash.contributor.affiliatedXu, Yingjie
dash.contributor.affiliatedZetter, Bruce
dash.contributor.affiliatedWu, Jun
dash.contributor.affiliatedShi, Jinjun
dash.contributor.affiliatedFarokhzad, Omid


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