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dc.contributor.authorWhitfield-Gabrieli, S.
dc.contributor.authorThermenos, Heidi Wencel
dc.contributor.authorMilanovic, Snezana M.
dc.contributor.authorTsuang, Ming T.
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorGreen, Alan Ivan
dc.contributor.authorNieto-Castanon, A.
dc.contributor.authorLaViolette, P.
dc.contributor.authorWojcik, Joanne Doller
dc.contributor.authorGabrieli, John D.E.
dc.contributor.authorSeidman, Larry Joel
dc.date.accessioned2016-10-25T20:11:27Z
dc.date.issued2009
dc.identifier.citationWhitfield-Gabrieli, S., H. W. Thermenos, S. Milanovic, M. T. Tsuang, S. V. Faraone, R. W. McCarley, M. E. Shenton, et al. 2009. Hyperactivity and Hyperconnectivity of the Default Network in Schizophrenia and in First-Degree Relatives of Persons with Schizophrenia. Proceedings of the National Academy of Sciences 106, no. 4: 1279–1284. doi:10.1073/pnas.0809141106.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29068005
dc.description.abstractWe examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working memory (WM) tasks. As expected, controls exhibited task-related suppression of activation in the default network, including medial prefrontal cortex (MPFC) and posterior cingulate cortex/precuneus. Patients and relatives exhibited significantly reduced task-related suppression in MPFC, and these reductions remained after controlling for performance. Increased task-related MPFC suppression correlated with better WM performance in patients and relatives and with less psychopathology in all 3 groups. For WM task performance, patients and relatives had greater activation in right dorsolateral prefrontal cortex (DLPFC) than controls. During rest and task, patients and relatives exhibited abnormally high functional connectivity within the default network. The magnitudes of default network connectivity during rest and task correlated with psychopathology in the patients. Further, during both rest and task, patients exhibited reduced anticorrelations between MPFC and DLPFC, a region that was hyperactivated by patients and relatives during WM performance. Among patients, the magnitude of MPFC task suppression negatively correlated with default connectivity, suggesting an association between the hyperactivation and hyperconnectivity in schizophrenia. Hyperactivation (reduced task-related suppression) of default regions and hyperconnectivity of the default network may contribute to disturbances of thought in schizophrenia and risk for the illness.en_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.0809141106en_US
dash.licenseLAA
dc.subjectpsychopathologyen_US
dc.subjectworking memoryen_US
dc.subjectfMRIen_US
dc.subjectfunctional connectivityen_US
dc.subjectgenetic risken_US
dc.titleHyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-10-25T20:11:27Z
dc.identifier.doi10.1073/pnas.0809141106*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedMilanovic, Snezana M.
dash.contributor.affiliatedGreen, Alan
dash.contributor.affiliatedThermenos, Heidi
dash.contributor.affiliatedWojcik, Joanne
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedTsuang, Ming
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedGabrieli, John
dash.contributor.affiliatedShenton, Martha
dash.contributor.affiliatedFaraone, Stephen
dc.identifier.orcid0000-0001-5705-7495


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