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dc.contributor.authorSpencer, Kevin M.
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorPerlmutter, R.
dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorKlump, M. C.
dc.contributor.authorFrumin, Melissa
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorMcCarley, Robert William
dc.date.accessioned2016-10-25T20:11:59Z
dc.date.issued2004
dc.identifier.citationSpencer, K. M., P. G. Nestor, R. Perlmutter, M. A. Niznikiewicz, M. C. Klump, M. Frumin, M. E. Shenton, and R. W. McCarley. 2004. Neural Synchrony Indexes Disordered Perception and Cognition in Schizophrenia. Proceedings of the National Academy of Sciences 101, no. 49: 17288–17293. doi:10.1073/pnas.0406074101.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29068585
dc.description.abstractCurrent views of schizophrenia suggest that it results from abnormalities in neural circuitry, but empirical evidence in the millisecond range of neural activity has been difficult to obtain. In pursuit of relevant evidence, we previously demonstrated that schizophrenia is associated with abnormal patterns of stimulus-evoked phaselocking of the electroencephalogram in the γ band (30–100 Hz). These patterns may reflect impairments in neural assemblies, which have been proposed to use γ-band oscillations as a mechanism for synchronization. Here, we report the unique finding that, in both healthy controls and schizophrenia patients, visual Gestalt stimuli elicit a γ-band oscillation that is phase-locked to reaction time and hence may reflect processes leading to conscious perception of the stimuli. However, the frequency of this oscillation is lower in schizophrenics than in healthy individuals. This finding suggests that, although synchronization must occur for perception of the Gestalt, it occurs at a lower frequency because of a reduced capability of neural networks to support high-frequency synchronization in the brain of schizophrenics. Furthermore, the degree of phase locking of this oscillation is correlated with visual hallucinations, thought disorder, and disorganization in the schizophrenia patients. These data provide support for linking dysfunctional neural circuitry and the core symptoms of schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.0406074101en_US
dash.licenseLAA
dc.subjectelectroencephalogramen_US
dc.subjectγ banden_US
dc.titleNeural synchrony indexes disordered perception and cognition in schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-10-25T20:11:59Z
dc.identifier.doi10.1073/pnas.0406074101*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedFrumin, Melissa
dash.contributor.affiliatedSpencer, Kevin
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


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