Molecule-hugging graphene nanopores

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Molecule-hugging graphene nanopores

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Title: Molecule-hugging graphene nanopores
Author: Garaj, S; Liu, Song; Golovchenko, Jene Andrew; Branton, Daniel

Note: Order does not necessarily reflect citation order of authors.

Citation: Garaj, S., S. Liu, J. A. Golovchenko, and D. Branton. 2013. Molecule-Hugging Graphene Nanopores. Proceedings of the National Academy of Sciences 110, no. 30: 12192–12196. doi:10.1073/pnas.1220012110.
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Abstract: It has recently been recognized that solid-state nanopores in single-atomic-layer graphene membranes can be used to electronically detect and characterize single long charged polymer molecules. We have now fabricated nanopores in single-layer graphene that are closely matched to the diameter of a double-stranded DNA molecule. Ionic current signals during electrophoretically driven translocation of DNA through these nanopores were experimentally explored and theoretically modeled. Our experiments show that these nanopores have unusually high sensitivity (0.65 nA/Å) to extremely small changes in the translocating molecule’s outer diameter. Such atomically short graphene nanopores can also resolve nanoscale-spaced molecular structures along the length of a polymer, but do so with greatest sensitivity only when the pore and molecule diameters are closely matched. Modeling confirms that our most closely matched pores have an inherent resolution of ≤0.6 nm along the length of the molecule.
Published Version: doi:10.1073/pnas.1220012110
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29071925
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