Biofunctionalized targeted nanoparticles for therapeutic applications

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Biofunctionalized targeted nanoparticles for therapeutic applications

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Title: Biofunctionalized targeted nanoparticles for therapeutic applications
Author: Wang, Andrew Z; Gu, Frank; Zhang, Liangfang; Chan, Juliana M; Radovic-Moreno, Aleksander; Shaikh, Mariam R; Farokhzad, Omid Cameron

Note: Order does not necessarily reflect citation order of authors.

Citation: Wang, Andrew Z, Frank Gu, Liangfang Zhang, Juliana M Chan, Aleksander Radovic-Moreno, Mariam R Shaikh, and Omid C Farokhzad. 2008. Biofunctionalized Targeted Nanoparticles for Therapeutic Applications. Expert Opinion on Biological Therapy 8 (8) (July 9): 1063–1070. doi:10.1517/14712598.8.8.1063.
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Abstract: Background: The development of nanoparticles for the delivery of therapeutic agents has introduced new opportunities for improvement in medical treatment. Recent efforts have focused on developing targeted nanoparticles for therapeutic delivery by functionalizing nanoparticle surfaces with targeting molecules, such as antibodies, peptides, small molecules and oligonucleotides.

Objectives: This paper will review the state of targeted nanoparticles development.

Methods: We will discuss nanoparticle platforms for therapeutic delivery, targeting molecules and the biofunctionalized targeted nanoparticles currently in development.

Results/Conclusions: Biofunctionalized targeted nanoparticles have demonstrated exciting data in preclinical studies. With continued improvements, they may fulfill their potential as therapeutics carriers that can truly treat target tissue without affecting normal cells.
Published Version: doi:10.1517/14712598.8.8.1063
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