Meiotic Adaptation to Genome Duplication in Arabidopsis arenosa

DSpace/Manakin Repository

Meiotic Adaptation to Genome Duplication in Arabidopsis arenosa

Citable link to this page


Title: Meiotic Adaptation to Genome Duplication in Arabidopsis arenosa
Author: Yant, Levi; Hollister, J; Wright, K; Arnold, Brian John; Higgins, James D.; Franklin, F. Chris H.; Bomblies, Kirsten

Note: Order does not necessarily reflect citation order of authors.

Citation: Yant, Levi, Jesse D. Hollister, Kevin M. Wright, Brian J. Arnold, James D. Higgins, F. Chris H. Franklin, and Kirsten Bomblies. 2013. Meiotic Adaptation to Genome Duplication in Arabidopsis Arenosa. Current Biology 23, no. 21: 2151–2156. doi:10.1016/j.cub.2013.08.059.
Full Text & Related Files:
Abstract: Whole genome duplication (WGD) is a major factor in the evolution of multicellular eukaryotes, yet by doubling the number of homologs, WGD severely challenges reliable chromosome segregation [1, 2, 3], a process conserved across kingdoms [4]. Despite this, numerous genomeduplicated (polyploid) species persist in nature, indicating early problems can be overcome [1, 2]. Little is known about which genes are involved – only one has been molecularly characterized [5]. To gain new insights into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of differentiation between natural diploids and tetraploids of Arabidopsis arenosa, an outcrossing relative of A. thaliana [6, 7]. We first show that diploids are not preadapted to polyploid meiosis. We then use a genome scanning approach to show that while polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 44 genes. These are discrete, mostly single-gene peaks of sharply elevated differentiation. Among these peaks are eight meiosis genes whose encoded proteins coordinate a specific subset of early meiotic functions, suggesting these genes comprise a polygenic solution to WGD-associated chromosome segregation challenges. Our findings indicate that even conserved meiotic processes can be capable of nimble evolutionary shifts when required.
Published Version: doi:10.1016/j.cub.2013.08.059
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search