Key clinical beam parameters for nanoparticle-mediated radiation dose amplification
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Author
Drané, Pascal
Kotb, Shady
Biancur, Douglas E.
Ireland, Thomas
Wagar, Matthew
Lux, Francois
Tillement, Olivier
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/srep34040Metadata
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Detappe, A., S. Kunjachan, P. Drané, S. Kotb, M. Myronakis, D. E. Biancur, T. Ireland, et al. 2016. “Key clinical beam parameters for nanoparticle-mediated radiation dose amplification.” Scientific Reports 6 (1): 34040. doi:10.1038/srep34040. http://dx.doi.org/10.1038/srep34040.Abstract
As nanoparticle solutions move towards human clinical trials in radiation therapy, the influence of key clinical beam parameters on therapeutic efficacy must be considered. In this study, we have investigated the clinical radiation therapy delivery variables that may significantly affect nanoparticle-mediated radiation dose amplification. We found a benefit for situations which increased the proportion of low energy photons in the incident beam. Most notably, “unflattened” photon beams from a clinical linear accelerator results in improved outcomes relative to conventional “flat” beams. This is measured by significant DNA damage, tumor growth suppression, and overall improvement in survival in a pancreatic tumor model. These results, obtained in a clinical setting, clearly demonstrate the influence and importance of radiation therapy parameters that will impact clinical radiation dose amplification with nanoparticles.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034311/pdf/Terms of Use
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