Micro-optical coherence tomography of the mammalian cochlea

DSpace/Manakin Repository

Micro-optical coherence tomography of the mammalian cochlea

Citable link to this page


Title: Micro-optical coherence tomography of the mammalian cochlea
Author: Iyer, Janani S.; Batts, Shelley A.; Chu, Kengyeh K.; Sahin, Mehmet I.; Leung, Hui Min; Tearney, Guillermo J.; Stankovic, Konstantina M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Iyer, Janani S., Shelley A. Batts, Kengyeh K. Chu, Mehmet I. Sahin, Hui Min Leung, Guillermo J. Tearney, and Konstantina M. Stankovic. 2016. “Micro-optical coherence tomography of the mammalian cochlea.” Scientific Reports 6 (1): 33288. doi:10.1038/srep33288. http://dx.doi.org/10.1038/srep33288.
Full Text & Related Files:
Abstract: The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual’s cochlear pathology and hearing function, and otologists must rely on physiological testing and imaging methods that offer limited resolution to obtain information about the inner ear prior to performing surgery. Micro-optical coherence tomography (μOCT) is a non-invasive, low-coherence interferometric imaging technique capable of resolving cellular-level anatomic structures. To determine whether μOCT is capable of resolving mammalian intracochlear anatomy, fixed guinea pig inner ears were imaged as whole temporal bones with cochlea in situ. Anatomical structures such as the tunnel of Corti, space of Nuel, modiolus, scalae, and cell groupings were visualized, in addition to individual cell types such as neuronal fibers, hair cells, and supporting cells. Visualization of these structures, via volumetrically-reconstructed image stacks and endoscopic perspective videos, represents an improvement over previous efforts using conventional OCT. These are the first μOCT images of mammalian cochlear anatomy, and they demonstrate μOCT’s potential utility as an imaging tool in otology research.
Published Version: doi:10.1038/srep33288
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025881/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407789
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search