Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

DSpace/Manakin Repository

Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Citable link to this page

 

 
Title: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
Author: Chahal, Harvind S.; Wu, Wenting; Ransohoff, Katherine J.; Yang, Lingyao; Hedlin, Haley; Desai, Manisha; Lin, Yuan; Dai, Hong-Ji; Qureshi, Abrar A.; Li, Wen-Qing; Kraft, Peter; Hinds, David A.; Tang, Jean Y.; Han, Jiali; Sarin, Kavita Y.

Note: Order does not necessarily reflect citation order of authors.

Citation: Chahal, H. S., W. Wu, K. J. Ransohoff, L. Yang, H. Hedlin, M. Desai, Y. Lin, et al. 2016. “Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.” Nature Communications 7 (1): 12510. doi:10.1038/ncomms12510. http://dx.doi.org/10.1038/ncomms12510.
Full Text & Related Files:
Abstract: Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10−8, logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.
Published Version: doi:10.1038/ncomms12510
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992160/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407809
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters