Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes

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Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes

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Title: Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes
Author: Reis, Surya A.; Ghosh, Balaram; Hendricks, J. Adam; Szantai-Kis, D. Miklos; Törk, Lisa; Ross, Kenneth N.; Lamb, Justin; Read-Button, Willis; Zheng, Baixue; Wang, Hongtao; Salthouse, Christopher; Haggarty, Stephen J.; Mazitschek, Ralph

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Citation: Reis, S. A., B. Ghosh, J. A. Hendricks, D. M. Szantai-Kis, L. Törk, K. N. Ross, J. Lamb, et al. 2016. “Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes.” Nature chemical biology 12 (5): 317-323. doi:10.1038/nchembio.2042. http://dx.doi.org/10.1038/nchembio.2042.
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Abstract: Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to advancing our understanding of the underlying molecular mechanisms of epigenetic processes. However, the resolution offered by small molecules is often insufficient to manipulate epigenetic processes with high spatio-temporal control. Here, we present a novel and generalizable approach, referred to as ‘Chemo-Optical Modulation of Epigenetically-regulated Transcription’ (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light. COMET probes may translate into novel therapeutic strategies for diseases where conditional and selective epigenome modulation is required.
Published Version: doi:10.1038/nchembio.2042
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836974/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407867
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