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dc.contributor.authorLin, Gen‐Minen_US
dc.contributor.authorRedline, Susanen_US
dc.contributor.authorKlein, Ronalden_US
dc.contributor.authorColangelo, Laura A.en_US
dc.contributor.authorCotch, Mary Francesen_US
dc.contributor.authorWong, Tien Y.en_US
dc.contributor.authorKlein, Barbara E. K.en_US
dc.contributor.authorPatel, Sanjay R.en_US
dc.contributor.authorShea, Steven J.en_US
dc.contributor.authorLiu, Kiangen_US
dc.date.accessioned2016-11-18T20:08:04Z
dc.date.issued2016en_US
dc.identifier.citationLin, Gen‐Min, Susan Redline, Ronald Klein, Laura A. Colangelo, Mary Frances Cotch, Tien Y. Wong, Barbara E. K. Klein, Sanjay R. Patel, Steven J. Shea, and Kiang Liu. 2016. “Sex‐Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi‐Ethnic Study of Atherosclerosis.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 5 (7): e003598. doi:10.1161/JAHA.116.003598. http://dx.doi.org/10.1161/JAHA.116.003598.en
dc.identifier.issn2047-9980en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29407880
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is a common condition affecting more men than women. The relationship of OSA with microvascular disease is unclear, complicated by possible sex difference. Assessment of the relationship of OSA with retinal microvascular signs in men and women may provide insights into such a relationship. Methods and Results: We examined the sex‐specific cross‐sectional association of OSA severity with retinal vascular calibers in 1808 participants, and with specific retinopathy signs in 1831 participants from a sample of 2060 participants aged 54 to 93 years who underwent successful polysomnography in the Multi‐Ethnic Study of Atherosclerosis, 2010–2012. OSA severity was defined by the apnea–hypopnea index (events/h) as none (<5), mild (5–14.9), moderate (15–29.9), and severe (≥30). As compared to no OSA, moderate/severe OSA in men was associated with retinal arteriolar narrowing (odds ratio [OR] and 95% CI for the narrowest quartile: 1.65 [1.00–2.71]) and retinal venular widening (1.80 [1.07–3.04] for the widest quartile), but not in women (odds ratio: 1.10 [0.67–1.81] and 0.91 [0.58–1.43], respectively) after adjusting for age, race/ethnicity, body mass index, pack‐years of cigarette smoking, alcohol intake, hypertension duration, diabetes mellitus duration, HbA1c levels, lipid profile, micro‐/macroalbuminuria, estimated glomerular filtration rate, β‐blockers use, antihypertensive therapy, and lipid‐lowering therapy. In contrast, severe OSA was associated with retinal microaneurysms in women, but not in men (odds ratio: 3.22 [1.16–8.97] and 0.59 [0.27–1.30], respectively). Conclusions: The associations of OSA severity with retinal microvascular signs may differ by sex. Whether these findings were related to sex differences in OSA exposure needs further investigation.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1161/JAHA.116.003598en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015394/pdf/en
dash.licenseLAAen_US
dc.subjectapnea‐hypopnea indexen
dc.subjectepidemiologyen
dc.subjectmicrovascular dysfunctionen
dc.subjectobstructive sleep apneaen
dc.subjectretinal vascular calibersen
dc.subjectretinopathyen
dc.subjectsex‐specificen
dc.subjectEpidemiologyen
dc.subjectLifestyleen
dc.subjectPrimary Preventionen
dc.subjectRisk Factorsen
dc.titleSex‐Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi‐Ethnic Study of Atherosclerosisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseaseen
dash.depositing.authorRedline, Susanen_US
dc.date.available2016-11-18T20:08:04Z
dc.identifier.doi10.1161/JAHA.116.003598*
dash.authorsorderedfalse
dash.contributor.affiliatedRedline, Susan


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