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dc.contributor.authorKhankari, Nikhil K.en_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorWen, Wanqingen_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorLindström, Saraen_US
dc.contributor.authorPeters, Ulrikeen_US
dc.contributor.authorSchildkraut, Joellenen_US
dc.contributor.authorSchumacher, Fredricken_US
dc.contributor.authorBofetta, Paoloen_US
dc.contributor.authorRisch, Angelaen_US
dc.contributor.authorBickeböller, Heikeen_US
dc.contributor.authorAmos, Christopher I.en_US
dc.contributor.authorEaston, Douglasen_US
dc.contributor.authorEeles, Rosalind A.en_US
dc.contributor.authorGruber, Stephen B.en_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorChanock, Stephen J.en_US
dc.contributor.authorPierce, Brandon L.en_US
dc.contributor.authorZheng, Weien_US
dc.date.accessioned2016-11-18T20:08:06Z
dc.date.issued2016en_US
dc.identifier.citationKhankari, N. K., X. Shu, W. Wen, P. Kraft, S. Lindström, U. Peters, J. Schildkraut, et al. 2016. “Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.” PLoS Medicine 13 (9): e1002118. doi:10.1371/journal.pmed.1002118. http://dx.doi.org/10.1371/journal.pmed.1002118.en
dc.identifier.issn1549-1277en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29407885
dc.description.abstractBackground: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings: A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Using meta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height with cancer risk. Mendelian randomization analyses were conducted using summary statistics obtained for 423 genetic variants identified from a recent GWAS of adult height and from a cancer genetics consortium study of multiple cancers that included 47,800 cases and 81,353 controls. For a 10-cm increase in height, the summary relative risks derived from the meta-analyses of prospective studies were 1.12 (95% CI 1.10, 1.15), 1.07 (95% CI 1.05, 1.10), and 1.06 (95% CI 1.02, 1.11) for colorectal, prostate, and lung cancers, respectively. Mendelian randomization analyses showed increased risks of colorectal (odds ratio [OR] = 1.58, 95% CI 1.14, 2.18) and lung cancer (OR = 1.10, 95% CI 1.00, 1.22) associated with each 10-cm increase in genetically predicted height. No association was observed for prostate cancer (OR = 1.03, 95% CI 0.92, 1.15). Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate. Conclusions: Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pmed.1002118en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012582/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectOncologyen
dc.subjectCancers and Neoplasmsen
dc.subjectGenitourinary Tract Tumorsen
dc.subjectProstate Canceren
dc.subjectUrologyen
dc.subjectProstate Diseasesen
dc.subjectMathematical and Statistical Techniquesen
dc.subjectStatistical Methodsen
dc.subjectMeta-Analysisen
dc.subjectPhysical Sciencesen
dc.subjectMathematicsen
dc.subjectStatistics (Mathematics)en
dc.subjectLung and Intrathoracic Tumorsen
dc.subjectProspective Studiesen
dc.subjectColorectal Canceren
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectExocrine Glandsen
dc.subjectProstate Glanden
dc.subjectComputational Biologyen
dc.subjectGenome Analysisen
dc.subjectGenome-Wide Association Studiesen
dc.subjectGeneticsen
dc.subjectGenomicsen
dc.subjectHuman Geneticsen
dc.subjectSocial Sciencesen
dc.subjectSociologyen
dc.subjectConsortiaen
dc.titleAssociation between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analysesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Medicineen
dash.depositing.authorKraft, Peteren_US
dc.date.available2016-11-18T20:08:06Z
dc.identifier.doi10.1371/journal.pmed.1002118*
dash.authorsorderedfalse
dash.contributor.affiliatedKraft, Phillip
dash.contributor.affiliatedHunter, David


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