Cold Water Fish Gelatin Methacryloyl Hydrogel for Tissue Engineering Application
Yoon, Hee Jeong
Shin, Su Ryon
Cha, Jae Min
Do, Jeong Tae
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CitationYoon, Hee Jeong, Su Ryon Shin, Jae Min Cha, Soo-Hong Lee, Jin-Hoi Kim, Jeong Tae Do, Hyuk Song, and Hojae Bae. 2016. “Cold Water Fish Gelatin Methacryloyl Hydrogel for Tissue Engineering Application.” PLoS ONE 11 (10): e0163902. doi:10.1371/journal.pone.0163902. http://dx.doi.org/10.1371/journal.pone.0163902.
AbstractGelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. Thus far, however, GelMA is mostly obtained from mammalian sources, which are associated with a risk of transmission of diseases, such as mad cow disease, as well as certain religious restrictions. In this study, we synthesized GelMA using fish-derived gelatin by a conventional GelMA synthesis method, and evaluated its physical properties and cell responses. The lower melting point of fish gelatin compared to porcine gelatin allowed larger-scale synthesis of GelMA and enabled hydrogel fabrication at room temperature. The properties (mechanical strength, water swelling degree and degradation rate) of fish GelMA differed from those of porcine GelMA, and could be tuned to suit diverse applications. Cells adhered, proliferated, and formed networks with surrounding cells on fish GelMA, and maintained high initial cell viability. These data suggest that fish GelMA could be utilized in a variety of biomedical fields as a substitute for mammalian-derived materials.
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