Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study

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Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study

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Title: Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study
Author: Takiguchi, Shinichiro; Fujisawa, Takashi X.; Mizushima, Sakae; Saito, Daisuke N.; Okamoto, Yuko; Shimada, Koji; Koizumi, Michiko; Kumazaki, Hirokazu; Jung, Minyoung; Kosaka, Hirotaka; Hiratani, Michio; Ohshima, Yusei; Teicher, Martin H.; Tomoda, Akemi

Note: Order does not necessarily reflect citation order of authors.

Citation: Takiguchi, S., T. X. Fujisawa, S. Mizushima, D. N. Saito, Y. Okamoto, K. Shimada, M. Koizumi, et al. 2015. “Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study.” BJPsych open 1 (2): 121-128. doi:10.1192/bjpo.bp.115.001586. http://dx.doi.org/10.1192/bjpo.bp.115.001586.
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Abstract: Background: Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD). Aims To examine whether neural activity during reward processing was altered in children and adolescents with RAD. Method Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging. Results: Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups. Conclusions: Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology. Declaration of interest None. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
Published Version: doi:10.1192/bjpo.bp.115.001586
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995568/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408218
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