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dc.contributor.authorKitsak, Maksimen_US
dc.contributor.authorSharma, Amitabhen_US
dc.contributor.authorMenche, Jörgen_US
dc.contributor.authorGuney, Emreen_US
dc.contributor.authorGhiassian, Susan Dinaen_US
dc.contributor.authorLoscalzo, Josephen_US
dc.contributor.authorBarabási, Albert-Lászlóen_US
dc.date.accessioned2016-11-18T20:47:02Z
dc.date.issued2016en_US
dc.identifier.citationKitsak, Maksim, Amitabh Sharma, Jörg Menche, Emre Guney, Susan Dina Ghiassian, Joseph Loscalzo, and Albert-László Barabási. 2016. “Tissue Specificity of Human Disease Module.” Scientific Reports 6 (1): 35241. doi:10.1038/srep35241. http://dx.doi.org/10.1038/srep35241.en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29408308
dc.description.abstractGenes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical manifestations of genetic diseases are usually highly tissue-specific. Although some disease genes are expressed only in selected tissues, the expression patterns of disease genes alone cannot explain the observed tissue specificity of human diseases. Here we hypothesize that for a disease to manifest itself in a particular tissue, a whole functional subnetwork of genes (disease module) needs to be expressed in that tissue. Driven by this hypothesis, we conducted a systematic study of the expression patterns of disease genes within the human interactome. We find that genes expressed in a specific tissue tend to be localized in the same neighborhood of the interactome. By contrast, genes expressed in different tissues are segregated in distinct network neighborhoods. Most important, we show that it is the integrity and the completeness of the expression of the disease module that determines disease manifestation in selected tissues. This approach allows us to construct a disease-tissue network that confirms known and predicts unexpected disease-tissue associations.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep35241en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066219/pdf/en
dash.licenseLAAen_US
dc.titleTissue Specificity of Human Disease Moduleen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorSharma, Amitabhen_US
dc.date.available2016-11-18T20:47:02Z
dc.identifier.doi10.1038/srep35241*
dash.contributor.affiliatedSharma, Amitabh
dash.contributor.affiliatedLoscalzo, Joseph
dash.contributor.affiliatedBarabasi, Albert-Laszlo


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