dc.contributor.author | Morrow, Monica | en_US |
dc.contributor.author | Van Zee, Kimberly J. | en_US |
dc.contributor.author | Solin, Lawrence J. | en_US |
dc.contributor.author | Houssami, Nehmat | en_US |
dc.contributor.author | Chavez-MacGregor, Mariana | en_US |
dc.contributor.author | Harris, Jay R. | en_US |
dc.contributor.author | Horton, Janet | en_US |
dc.contributor.author | Hwang, Shelley | en_US |
dc.contributor.author | Johnson, Peggy L. | en_US |
dc.contributor.author | Marinovich, M. Luke | en_US |
dc.contributor.author | Schnitt, Stuart J. | en_US |
dc.contributor.author | Wapnir, Irene | en_US |
dc.contributor.author | Moran, Meena S. | en_US |
dc.date.accessioned | 2016-11-18T20:47:04Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Morrow, M., K. J. Van Zee, L. J. Solin, N. Houssami, M. Chavez-MacGregor, J. R. Harris, J. Horton, et al. 2016. “Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ.” Annals of Surgical Oncology 23 (12): 3801-3810. doi:10.1245/s10434-016-5449-z. http://dx.doi.org/10.1245/s10434-016-5449-z. | en |
dc.identifier.issn | 1068-9265 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408312 | |
dc.description.abstract | Purpose Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation. Methods: A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a systematic review of 20 studies including 7,883 patients and other published literature as the evidence base for consensus. Results: Negative margins halve the risk of IBTR compared with positive margins defined as ink on DCIS. A 2-mm margin minimizes the risk of IBTR compared with smaller negative margins. More widely clear margins do not significantly decrease IBTR compared with 2-mm margins. Negative margins narrower than 2 mm alone are not an indication for mastectomy, and factors known to affect rates of IBTR should be considered in determining the need for re-excision. Conclusion: Use of a 2-mm margin as the standard for an adequate margin in DCIS treated with whole-breast irradiation is associated with lower rates of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcomes, and decrease health care costs. Clinical judgment should be used in determining the need for further surgery in patients with negative margins narrower than 2 mm. | en |
dc.language.iso | en_US | en |
dc.publisher | Springer International Publishing | en |
dc.relation.isversionof | doi:10.1245/s10434-016-5449-z | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047939/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Annals of Surgical Oncology | en |
dash.depositing.author | Harris, Jay R. | en_US |
dc.date.available | 2016-11-18T20:47:04Z | |
dc.identifier.doi | 10.1245/s10434-016-5449-z | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Harris, Jay | |
dash.contributor.affiliated | Schnitt, Stuart | |