Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies

DSpace/Manakin Repository

Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies

Citable link to this page

 

 
Title: Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies
Author: Ruella, Marco; Maus, Marcela V.

Note: Order does not necessarily reflect citation order of authors.

Citation: Ruella, Marco, and Marcela V. Maus. 2016. “Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies.” Computational and Structural Biotechnology Journal 14 (1): 357-362. doi:10.1016/j.csbj.2016.09.003. http://dx.doi.org/10.1016/j.csbj.2016.09.003.
Full Text & Related Files:
Abstract: Immunotherapy is the revolution in cancer treatment of this last decade. Among multiple approaches able to harness the power of the immune system against cancer, T cell based immunotherapies represent one of the most successful examples. In particular, biotechnological engineering of protein structures, like the T cell receptor or the immunoglobulins, allowed the generation of synthetic peptides like chimeric antigen receptors and bispecific antibodies that are able to redirect non-tumor specific T cells to recognize and kill leukemic cells. The anti-CD19/CD3 bispecific antibody blinatumomab and anti-CD19 chimeric antigen receptor T cells (CART19) have produced deep responses in patients with relapsed and refractory B-cell acute leukemias. However, although the majority of these patients responds to anti-CD19 immunotherapy, a subset of them still relapses. Interestingly, a novel family of leukemia escape mechanisms has been described, all characterized by the apparent loss of CD19 on the surface of leukemic blasts. This extraordinary finding demonstrates the potent selective pressure of CART19/blinatumomab that drives extreme and specific escape strategies by leukemic blasts. Patients with CD19-negative relapsed leukemia have very poor prognosis and novel approaches to treat and ideally prevent antigen-loss are direly needed. In this review we discuss the incidence, mechanisms and therapeutic approaches for CD19-negative leukemia relapses occuring after CD19-directed T cell immunotherapies and present our future perspective.
Published Version: doi:10.1016/j.csbj.2016.09.003
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061074/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408316
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters