Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

 
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Okbay, Aysu
Baselmans, Bart M.L.
De Neve, Jan-Emmanuel
Turley, Patrick
Nivard, Michel G.
Fontana, Mark Alan
Meddens, S. Fleur W.
Linnér, Richard Karlsson
Rietveld, Cornelius A.
Derringer, Jaime
Gratten, Jacob
Lee, James J.
Liu, Jimmy Z.
de Vlaming, Ronald
Ahluwalia, Tarunveer S.
Buchwald, Jadwiga
Cavadino, Alana
Frazier-Wood, Alexis C.
Furlotte, Nicholas A.
Garfield, Victoria
Geisel, Marie Henrike
Gonzalez, Juan R.
Haitjema, Saskia
Karlsson, Robert
van der Laan, Sander W.
Ladwig, Karl-Heinz
Lahti, Jari
van der Lee, Sven J.
Lind, Penelope A.
Liu, Tian
Matteson, Lindsay
Mihailov, Evelin
Miller, Michael B.
Minica, Camelia C.
Nolte, Ilja M.
Mook-Kanamori, Dennis
van der Most, Peter J.
Oldmeadow, Christopher
Qian, Yong
Raitakari, Olli
Rawal, Rajesh
Realo, Anu
Rueedi, Rico
Schmidt, Börge
Smith, Albert V.
Stergiakouli, Evie
Tanaka, Toshiko
Taylor, Kent
Wedenoja, Juho
Wellmann, Juergen
Willems, Sara M.
Zhao, Wei
Amin, Najaf
Bakshi, Andrew
Boyle, Patricia A.
Cherney, Samantha
Cox, Simon R.
Davies, Gail
Davis, Oliver S.P.
Ding, Jun
Direk, Nese
Eibich, Peter
Emeny, Rebecca T.
Fatemifar, Ghazaleh
Faul, Jessica D.
Ferrucci, Luigi
Forstner, Andreas
Gieger, Christian
Gupta, Richa
Harris, Tamara B.
Harris, Juliette M.
Holliday, Elizabeth G.
Hottenga, Jouke-Jan
Kaakinen, Marika A.
Kajantie, Eero
Karhunen, Ville
Kolcic, Ivana
Kumari, Meena
Launer, Lenore J.
Franke, Lude
Li-Gao, Ruifang
Koini, Marisa
Loukola, Anu
Marques-Vidal, Pedro
Montgomery, Grant W.
Mosing, Miriam A.
Paternoster, Lavinia
Pattie, Alison
Petrovic, Katja E.
Pulkki-Råback, Laura
Quaye, Lydia
Räikkönen, Katri
Rudan, Igor
Scott, Rodney J.
Smith, Jennifer A.
Sutin, Angelina R.
Trzaskowski, Maciej
Vinkhuyzen, Anna E.
Yu, Lei
Zabaneh, Delilah
Attia, John R.
Bennett, David A.
Berger, Klaus
Bertram, Lars
Boomsma, Dorret I.
Snieder, Harold
Cucca, Francesco
Deary, Ian J.
van Duijn, Cornelia M.
Eriksson, Johan G.
Bültmann, Ute
de Geus, Eco J.C.
Groenen, Patrick J.F.
Gudnason, Vilmundur
Hansen, Torben
Hartman, Catharine A.
Haworth, Claire M.A.
Hayward, Caroline
Heath, Andrew C.
Hinds, David A.
Hyppönen, Elina
Iacono, William G.
Järvelin, Marjo-Riitta
Jöckel, Karl-Heinz
Kaprio, Jaakko
Kardia, Sharon L.R.
Keltikangas-Järvinen, Liisa
Lehtimäki, Terho
Magnusson, Patrik K.E.
Martin, Nicholas G.
McGue, Matt
Metspalu, Andres
Mills, Melinda
de Mutsert, Renée
Oldehinkel, Albertine J.
Pasterkamp, Gerard
Pedersen, Nancy L.
Plomin, Robert
Polasek, Ozren
Power, Christine
Rich, Stephen S.
Rosendaal, Frits R.
den Ruijter, Hester M.
Schlessinger, David
Schmidt, Helena
Svento, Rauli
Schmidt, Reinhold
Alizadeh, Behrooz Z.
Sørensen, Thorkild I.A.
Spector, Tim D.
Steptoe, Andrew
Terracciano, Antonio
Thurik, A. Roy
Timpson, Nicholas J.
Tiemeier, Henning
Uitterlinden, André G.
Vollenweider, Peter
Wagner, Gert G.
Weir, David R.
Yang, Jian
Conley, Dalton C.
Smith, George Davey
Johannesson, Magnus
Medland, Sarah E.
Meyer, Michelle N.
Pickrell, Joseph K.
Esko, Tõnu
Krueger, Robert F.
Beauchamp, Jonathan P.
Koellinger, Philipp D.
Benjamin, Daniel J.
Bartels, Meike
Cesarini, David
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/ng.3552
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Citation
Okbay, A., B. M. Baselmans, J. De Neve, P. Turley, M. G. Nivard, M. A. Fontana, S. F. W. Meddens, et al. 2016. “Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses.” Nature genetics 48 (6): 624-633. doi:10.1038/ng.3552. http://dx.doi.org/10.1038/ng.3552.
Abstract
We conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The two depressive symptoms loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ̂| ≈ 0.8) strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are strongly enriched for association.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884152/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408364

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