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dc.contributor.authorOkbay, Aysuen_US
dc.contributor.authorBaselmans, Bart M.L.en_US
dc.contributor.authorDe Neve, Jan-Emmanuelen_US
dc.contributor.authorTurley, Patricken_US
dc.contributor.authorNivard, Michel G.en_US
dc.contributor.authorFontana, Mark Alanen_US
dc.contributor.authorMeddens, S. Fleur W.en_US
dc.contributor.authorLinnér, Richard Karlssonen_US
dc.contributor.authorRietveld, Cornelius A.en_US
dc.contributor.authorDerringer, Jaimeen_US
dc.contributor.authorGratten, Jacoben_US
dc.contributor.authorLee, James J.en_US
dc.contributor.authorLiu, Jimmy Z.en_US
dc.contributor.authorde Vlaming, Ronalden_US
dc.contributor.authorAhluwalia, Tarunveer S.en_US
dc.contributor.authorBuchwald, Jadwigaen_US
dc.contributor.authorCavadino, Alanaen_US
dc.contributor.authorFrazier-Wood, Alexis C.en_US
dc.contributor.authorFurlotte, Nicholas A.en_US
dc.contributor.authorGarfield, Victoriaen_US
dc.contributor.authorGeisel, Marie Henrikeen_US
dc.contributor.authorGonzalez, Juan R.en_US
dc.contributor.authorHaitjema, Saskiaen_US
dc.contributor.authorKarlsson, Roberten_US
dc.contributor.authorvan der Laan, Sander W.en_US
dc.contributor.authorLadwig, Karl-Heinzen_US
dc.contributor.authorLahti, Jarien_US
dc.contributor.authorvan der Lee, Sven J.en_US
dc.contributor.authorLind, Penelope A.en_US
dc.contributor.authorLiu, Tianen_US
dc.contributor.authorMatteson, Lindsayen_US
dc.contributor.authorMihailov, Evelinen_US
dc.contributor.authorMiller, Michael B.en_US
dc.contributor.authorMinica, Camelia C.en_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorMook-Kanamori, Dennisen_US
dc.contributor.authorvan der Most, Peter J.en_US
dc.contributor.authorOldmeadow, Christopheren_US
dc.contributor.authorQian, Yongen_US
dc.contributor.authorRaitakari, Ollien_US
dc.contributor.authorRawal, Rajeshen_US
dc.contributor.authorRealo, Anuen_US
dc.contributor.authorRueedi, Ricoen_US
dc.contributor.authorSchmidt, Börgeen_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorStergiakouli, Evieen_US
dc.contributor.authorTanaka, Toshikoen_US
dc.contributor.authorTaylor, Kenten_US
dc.contributor.authorWedenoja, Juhoen_US
dc.contributor.authorWellmann, Juergenen_US
dc.contributor.authorWestra, Harm-Janen_US
dc.contributor.authorWillems, Sara M.en_US
dc.contributor.authorZhao, Weien_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorBakshi, Andrewen_US
dc.contributor.authorBoyle, Patricia A.en_US
dc.contributor.authorCherney, Samanthaen_US
dc.contributor.authorCox, Simon R.en_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorDavis, Oliver S.P.en_US
dc.contributor.authorDing, Junen_US
dc.contributor.authorDirek, Neseen_US
dc.contributor.authorEibich, Peteren_US
dc.contributor.authorEmeny, Rebecca T.en_US
dc.contributor.authorFatemifar, Ghazalehen_US
dc.contributor.authorFaul, Jessica D.en_US
dc.contributor.authorFerrucci, Luigien_US
dc.contributor.authorForstner, Andreasen_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorGupta, Richaen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHarris, Juliette M.en_US
dc.contributor.authorHolliday, Elizabeth G.en_US
dc.contributor.authorHottenga, Jouke-Janen_US
dc.contributor.authorDe Jager, Philip L.en_US
dc.contributor.authorKaakinen, Marika A.en_US
dc.contributor.authorKajantie, Eeroen_US
dc.contributor.authorKarhunen, Villeen_US
dc.contributor.authorKolcic, Ivanaen_US
dc.contributor.authorKumari, Meenaen_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorFranke, Ludeen_US
dc.contributor.authorLi-Gao, Ruifangen_US
dc.contributor.authorKoini, Marisaen_US
dc.contributor.authorLoukola, Anuen_US
dc.contributor.authorMarques-Vidal, Pedroen_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorMosing, Miriam A.en_US
dc.contributor.authorPaternoster, Laviniaen_US
dc.contributor.authorPattie, Alisonen_US
dc.contributor.authorPetrovic, Katja E.en_US
dc.contributor.authorPulkki-Råback, Lauraen_US
dc.contributor.authorQuaye, Lydiaen_US
dc.contributor.authorRäikkönen, Katrien_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorScott, Rodney J.en_US
dc.contributor.authorSmith, Jennifer A.en_US
dc.contributor.authorSutin, Angelina R.en_US
dc.contributor.authorTrzaskowski, Maciejen_US
dc.contributor.authorVinkhuyzen, Anna E.en_US
dc.contributor.authorYu, Leien_US
dc.contributor.authorZabaneh, Delilahen_US
dc.contributor.authorAttia, John R.en_US
dc.contributor.authorBennett, David A.en_US
dc.contributor.authorBerger, Klausen_US
dc.contributor.authorBertram, Larsen_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorChang, Shun-Chiaoen_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorEriksson, Johan G.en_US
dc.contributor.authorBültmann, Uteen_US
dc.contributor.authorde Geus, Eco J.C.en_US
dc.contributor.authorGroenen, Patrick J.F.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorHartman, Catharine A.en_US
dc.contributor.authorHaworth, Claire M.A.en_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHeath, Andrew C.en_US
dc.contributor.authorHinds, David A.en_US
dc.contributor.authorHyppönen, Elinaen_US
dc.contributor.authorIacono, William G.en_US
dc.contributor.authorJärvelin, Marjo-Riittaen_US
dc.contributor.authorJöckel, Karl-Heinzen_US
dc.contributor.authorKaprio, Jaakkoen_US
dc.contributor.authorKardia, Sharon L.R.en_US
dc.contributor.authorKeltikangas-Järvinen, Liisaen_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorKubzansky, Laura D.en_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorMagnusson, Patrik K.E.en_US
dc.contributor.authorMartin, Nicholas G.en_US
dc.contributor.authorMcGue, Matten_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMills, Melindaen_US
dc.contributor.authorde Mutsert, Renéeen_US
dc.contributor.authorOldehinkel, Albertine J.en_US
dc.contributor.authorPasterkamp, Gerarden_US
dc.contributor.authorPedersen, Nancy L.en_US
dc.contributor.authorPlomin, Roberten_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPower, Christineen_US
dc.contributor.authorRich, Stephen S.en_US
dc.contributor.authorRosendaal, Frits R.en_US
dc.contributor.authorden Ruijter, Hester M.en_US
dc.contributor.authorSchlessinger, Daviden_US
dc.contributor.authorSchmidt, Helenaen_US
dc.contributor.authorSvento, Raulien_US
dc.contributor.authorSchmidt, Reinholden_US
dc.contributor.authorAlizadeh, Behrooz Z.en_US
dc.contributor.authorSørensen, Thorkild I.A.en_US
dc.contributor.authorSpector, Tim D.en_US
dc.contributor.authorSteptoe, Andrewen_US
dc.contributor.authorTerracciano, Antonioen_US
dc.contributor.authorThurik, A. Royen_US
dc.contributor.authorTimpson, Nicholas J.en_US
dc.contributor.authorTiemeier, Henningen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorVollenweider, Peteren_US
dc.contributor.authorWagner, Gert G.en_US
dc.contributor.authorWeir, David R.en_US
dc.contributor.authorYang, Jianen_US
dc.contributor.authorConley, Dalton C.en_US
dc.contributor.authorSmith, George Daveyen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorJohannesson, Magnusen_US
dc.contributor.authorLaibson, David I.en_US
dc.contributor.authorMedland, Sarah E.en_US
dc.contributor.authorMeyer, Michelle N.en_US
dc.contributor.authorPickrell, Joseph K.en_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorKrueger, Robert F.en_US
dc.contributor.authorBeauchamp, Jonathan P.en_US
dc.contributor.authorKoellinger, Philipp D.en_US
dc.contributor.authorBenjamin, Daniel J.en_US
dc.contributor.authorBartels, Meikeen_US
dc.contributor.authorCesarini, Daviden_US
dc.date.accessioned2016-11-18T20:47:52Z
dc.date.issued2016en_US
dc.identifier.citationOkbay, A., B. M. Baselmans, J. De Neve, P. Turley, M. G. Nivard, M. A. Fontana, S. F. W. Meddens, et al. 2016. “Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses.” Nature genetics 48 (6): 624-633. doi:10.1038/ng.3552. http://dx.doi.org/10.1038/ng.3552.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29408364
dc.description.abstractWe conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The two depressive symptoms loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ̂| ≈ 0.8) strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are strongly enriched for association.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.3552en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884152/pdf/en
dash.licenseLAAen_US
dc.titleGenetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analysesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorWestra, Harm-Janen_US
dc.date.available2016-11-18T20:47:52Z
dc.identifier.doi10.1038/ng.3552*
dash.authorsorderedfalse
dash.contributor.affiliatedWestra, Harm-Jan
dash.contributor.affiliatedDe Jager, Philip
dash.contributor.affiliatedKubzansky, Laura
dash.contributor.affiliatedChang, Shun-Chiao
dash.contributor.affiliatedKraft, Phillip
dash.contributor.affiliatedHofman, Albert
dash.contributor.affiliatedLaibson, David
dc.identifier.orcid0000-0002-9865-121X


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