CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

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CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

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Title: CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types
Author: Nelms, Bradlee D.; Waldron, Levi; Barrera, Luis A.; Weflen, Andrew W.; Goettel, Jeremy A.; Guo, Guoji; Montgomery, Robert K.; Neutra, Marian R.; Breault, David T.; Snapper, Scott B.; Orkin, Stuart H.; Bulyk, Martha L.; Huttenhower, Curtis; Lencer, Wayne I.

Note: Order does not necessarily reflect citation order of authors.

Citation: Nelms, B. D., L. Waldron, L. A. Barrera, A. W. Weflen, J. A. Goettel, G. Guo, R. K. Montgomery, et al. 2016. “CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types.” Genome Biology 17 (1): 201. doi:10.1186/s13059-016-1062-5. http://dx.doi.org/10.1186/s13059-016-1062-5.
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Abstract: We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our method, CellMapper, strongly outperforms previous computational algorithms to predict cell type-specific expression, especially for rare and difficult-to-isolate cell types. Furthermore, CellMapper makes accurate predictions for human brain cell types that have never been isolated, and can be rapidly applied to diverse cell types from many tissues. We demonstrate a clinically relevant application to prioritize candidate genes in disease susceptibility loci identified by GWAS. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1062-5) contains supplementary material, which is available to authorized users.
Published Version: doi:10.1186/s13059-016-1062-5
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043525/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408412
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