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dc.contributor.authorGong, Jianen_US
dc.contributor.authorHutter, Carolyn M.en_US
dc.contributor.authorNewcomb, Polly A.en_US
dc.contributor.authorUlrich, Cornelia M.en_US
dc.contributor.authorBien, Stephanie A.en_US
dc.contributor.authorCampbell, Peter T.en_US
dc.contributor.authorBaron, John A.en_US
dc.contributor.authorBerndt, Sonja I.en_US
dc.contributor.authorBezieau, Stephaneen_US
dc.contributor.authorBrenner, Hermannen_US
dc.contributor.authorCasey, Grahamen_US
dc.contributor.authorChan, Andrew T.en_US
dc.contributor.authorChang-Claude, Jennyen_US
dc.contributor.authorDu, Mengmengen_US
dc.contributor.authorDuggan, Daviden_US
dc.contributor.authorFigueiredo, Jane C.en_US
dc.contributor.authorGallinger, Stevenen_US
dc.contributor.authorGiovannucci, Edward L.en_US
dc.contributor.authorHaile, Robert W.en_US
dc.contributor.authorHarrison, Tabitha A.en_US
dc.contributor.authorHayes, Richard B.en_US
dc.contributor.authorHoffmeister, Michaelen_US
dc.contributor.authorHopper, John L.en_US
dc.contributor.authorHudson, Thomas J.en_US
dc.contributor.authorJeon, Jihyounen_US
dc.contributor.authorJenkins, Mark A.en_US
dc.contributor.authorKocarnik, Jonathanen_US
dc.contributor.authorKüry, Sébastienen_US
dc.contributor.authorLe Marchand, Loicen_US
dc.contributor.authorLin, Yien_US
dc.contributor.authorLindor, Noralane M.en_US
dc.contributor.authorNishihara, Reikoen_US
dc.contributor.authorOgino, Shujien_US
dc.contributor.authorPotter, John D.en_US
dc.contributor.authorRudolph, Anjaen_US
dc.contributor.authorSchoen, Robert E.en_US
dc.contributor.authorSchrotz-King, Petraen_US
dc.contributor.authorSeminara, Danielaen_US
dc.contributor.authorSlattery, Martha L.en_US
dc.contributor.authorThibodeau, Stephen N.en_US
dc.contributor.authorThornquist, Marken_US
dc.contributor.authorToth, Rekaen_US
dc.contributor.authorWallace, Roberten_US
dc.contributor.authorWhite, Emilyen_US
dc.contributor.authorJiao, Shuoen_US
dc.contributor.authorLemire, Mathieuen_US
dc.contributor.authorHsu, Lien_US
dc.contributor.authorPeters, Ulrikeen_US
dc.date.accessioned2016-11-18T20:48:41Z
dc.date.issued2016en_US
dc.identifier.citationGong, J., C. M. Hutter, P. A. Newcomb, C. M. Ulrich, S. A. Bien, P. T. Campbell, J. A. Baron, et al. 2016. “Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer.” PLoS Genetics 12 (10): e1006296. doi:10.1371/journal.pgen.1006296. http://dx.doi.org/10.1371/journal.pgen.1006296.en
dc.identifier.issn1553-7390en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29408423
dc.description.abstractGenome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are likely additional variants that are associated with CRC susceptibility. Genome-wide studies of gene-environment interactions may identify variants that are not detected in GWAS of marginal gene effects. To study this, we conducted a genome-wide analysis for interaction between genetic variants and alcohol consumption and cigarette smoking using data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Interactions were tested using logistic regression. We identified interaction between CRC risk and alcohol consumption and variants in the 9q22.32/HIATL1 (Pinteraction = 1.76×10−8; permuted p-value 3.51x10-8) region. Compared to non-/occasional drinking light to moderate alcohol consumption was associated with a lower risk of colorectal cancer among individuals with rs9409565 CT genotype (OR, 0.82 [95% CI, 0.74–0.91]; P = 2.1×10−4) and TT genotypes (OR,0.62 [95% CI, 0.51–0.75]; P = 1.3×10−6) but not associated among those with the CC genotype (p = 0.059). No genome-wide statistically significant interactions were observed for smoking. If replicated our suggestive finding of a genome-wide significant interaction between genetic variants and alcohol consumption might contribute to understanding colorectal cancer etiology and identifying subpopulations with differential susceptibility to the effect of alcohol on CRC risk.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pgen.1006296en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065124/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectNutritionen
dc.subjectDieten
dc.subjectAlcohol Consumptionen
dc.subjectMedicine and Health Sciencesen
dc.subjectOncologyen
dc.subjectCancers and Neoplasmsen
dc.subjectColorectal Canceren
dc.subjectGeneticsen
dc.subjectGene Expressionen
dc.subjectBehavioren
dc.subjectHabitsen
dc.subjectSmoking Habitsen
dc.subjectAnatomyen
dc.subjectDigestive Systemen
dc.subjectGastrointestinal Tracten
dc.subjectColonen
dc.subjectEpidemiologyen
dc.subjectGenetic Epidemiologyen
dc.subjectAdenomasen
dc.subjectComputational Biologyen
dc.subjectGenome Analysisen
dc.subjectGenome-Wide Association Studiesen
dc.subjectGenomicsen
dc.subjectHuman Geneticsen
dc.titleGenome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Canceren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Geneticsen
dash.depositing.authorChan, Andrew T.en_US
dc.date.available2016-11-18T20:48:41Z
dc.identifier.doi10.1371/journal.pgen.1006296*
dash.authorsorderedfalse
dash.contributor.affiliatedChan, Andrew
dash.contributor.affiliatedGiovannucci, Edward
dash.contributor.affiliatedOgino, Shuji
dash.contributor.affiliatedNakashima, Reiko


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