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dc.contributor.authorLagerweij, Tonnyen_US
dc.contributor.authorHiddingh, Lotteen_US
dc.contributor.authorBiesmans, Dennisen_US
dc.contributor.authorCrommentuijn, Matheus H.W.en_US
dc.contributor.authorCloos, Jacquelineen_US
dc.contributor.authorLi, Xiao-Nanen_US
dc.contributor.authorKogiso, Marien_US
dc.contributor.authorTannous, Bakhos A.en_US
dc.contributor.authorVandertop, W. Peteren_US
dc.contributor.authorNoske, David P.en_US
dc.contributor.authorKaspers, Gertjan J.L.en_US
dc.contributor.authorWürdinger, Tomen_US
dc.contributor.authorHulleman, Estheren_US
dc.date.accessioned2016-12-02T15:24:26Z
dc.date.issued2016en_US
dc.identifier.citationLagerweij, T., L. Hiddingh, D. Biesmans, M. H. Crommentuijn, J. Cloos, X. Li, M. Kogiso, et al. 2016. “A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer.” Oncotarget 7 (24): 35776-35788. doi:10.18632/oncotarget.7980. http://dx.doi.org/10.18632/oncotarget.7980.en
dc.identifier.issn1949-2553en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626020
dc.description.abstractTreatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medulloblastoma, we set out to identify novel drugs that could potentiate the effect of ionizing radiation. Thereto, a small molecule library, consisting of 960 chemical compounds, was screened for its ability to sensitize towards irradiation. This small molecule screen identified the flavonoid quercetin as a novel radiosensitizer for the medulloblastoma cell lines DAOY, D283-med, and, to a lesser extent, D458-med at low micromolar concentrations and irradiation doses used in fractionated radiation schemes. Quercetin did not affect the proliferation of neural precursor cells or normal human fibroblasts. Importantly, in vivo experiments confirmed the radiosensitizing properties of quercetin. Administration of this flavonoid at the time of irradiation significantly prolonged survival in orthotopically xenografted mice. Together, these findings indicate that quercetin is a potent radiosensitizer for medulloblastoma cells that may be a promising lead for the treatment of medulloblastoma in patients.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.isversionofdoi:10.18632/oncotarget.7980en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094961/pdf/en
dash.licenseLAAen_US
dc.subjectmedulloblastomaen
dc.subjectquercetinen
dc.subjectradiosensitizeren
dc.subjectsmall moleculeen
dc.subjectscreenen
dc.titleA chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizeren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncotargeten
dash.depositing.authorTannous, Bakhos A.en_US
dc.date.available2016-12-02T15:24:26Z
dc.identifier.doi10.18632/oncotarget.7980*
dash.authorsorderedfalse
dash.contributor.affiliatedTannous, Bakhos


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