Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds

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Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds

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Title: Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds
Author: Bruni, Giancarlo; Rennekamp, Andrew J.; Velenich, Andrea; McCarroll, Matthew; Gendelev, Leo; Fertsch, Ethan; Taylor, Jack; Lakhani, Parth; Lensen, Dennis; Evron, Tama; Lorello, Paul J.; Huang, Xi-Ping; Kolczewski, Sabine; Carey, Galen; Caldarone, Barbara J.; Prinssen, Eric; Roth, Bryan L.; Keiser, Michael J.; Peterson, Randall T.; Kokel, David

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Citation: Bruni, G., A. J. Rennekamp, A. Velenich, M. McCarroll, L. Gendelev, E. Fertsch, J. Taylor, et al. 2016. “Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds.” Nature chemical biology 12 (7): 559-566. doi:10.1038/nchembio.2097. http://dx.doi.org/10.1038/nchembio.2097.
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Abstract: Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping, and a large sampling of compounds, it should be possible to identify compounds with desired mechanisms of action based on their behavioral profiles alone. Although zebrafish (Danio rerio) behaviors have been used to rapidly identify neuroactive compounds, it remains unclear exactly what kind of behavioral assays might be necessary to identify multi-target compounds such as antipsychotics. Here, we developed a battery of behavioral assays in larval zebrafish to determine if behavioral profiles could provide sufficient phenotypic resolution to identify and classify psychiatric drugs. Using the antipsychotic drug haloperidol as a test case, we found that behavioral profiles of haloperidol-treated animals could be used to identify previously uncharacterized compounds with desired antipsychotic-like activities and multi-target mechanisms of action.
Published Version: doi:10.1038/nchembio.2097
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912417/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626045
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