Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

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Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

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Title: Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development
Author: Hellström, Ann; Ley, David; Hansen‐Pupp, Ingrid; Hallberg, Boubou; Löfqvist, Chatarina; van Marter, Linda; van Weissenbruch, Mirjam; Ramenghi, Luca A.; Beardsall, Kathryn; Dunger, David; Hård, Anna‐Lena; Smith, Lois E. H.

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Citation: Hellström, A., D. Ley, I. Hansen‐Pupp, B. Hallberg, C. Löfqvist, L. van Marter, M. van Weissenbruch, et al. 2016. “Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development.” Acta Paediatrica (Oslo, Norway : 1992) 105 (6): 576-586. doi:10.1111/apa.13350. http://dx.doi.org/10.1111/apa.13350.
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Abstract: Abstract Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed the role of IGF‐1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF‐1 deficiency in preterm morbidities. Conclusion: There is a rationale for clinical trials to evaluate the potential benefits of IGF‐1 replacement in very preterm infants.
Published Version: doi:10.1111/apa.13350
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069563/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626052
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