Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice

DSpace/Manakin Repository

Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice

Citable link to this page

 

 
Title: Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice
Author: Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D.

Note: Order does not necessarily reflect citation order of authors.

Citation: Cavalli, R. C., A. S. Cerdeira, E. Pernicone, H. A. Korkes, S. D. Burke, A. Rajakumar, R. I. Thadhani, et al. 2016. “Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice.” PLoS ONE 11 (10): e0164353. doi:10.1371/journal.pone.0164353. http://dx.doi.org/10.1371/journal.pone.0164353.
Full Text & Related Files:
Abstract: Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth restriction. Ex vivo manipulation of human peripheral blood NK (pNK) cells by a combination of hypoxia, TGFß-1 and 5-aza-2’-deoxycytidine yields cells with phenotypic and in vitro functional similarities to dNK cells, called idNK cells. Here, gene expression profiling shows that CD56Bright idNK cells derived ex vivo from human pNK cells, and to a lesser extent CD56Dim idNK cells, are enriched in the gene expression signature that distinguishes dNK cells from pNK cells. When injected into immunocompromised pregnant mice with elevated uterine artery resistance, idNK cells homed to the uterus and reduced the uterine artery resistance index, suggesting improved placental perfusion.
Published Version: doi:10.1371/journal.pone.0164353
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063315/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626057
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters