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dc.contributor.authorCavalli, Ricardo C.en_US
dc.contributor.authorCerdeira, Ana Sofiaen_US
dc.contributor.authorPernicone, Elizabethen_US
dc.contributor.authorKorkes, Henri A.en_US
dc.contributor.authorBurke, Suzanne D.en_US
dc.contributor.authorRajakumar, Augustineen_US
dc.contributor.authorThadhani, Ravi I.en_US
dc.contributor.authorRoberts, Drucilla J.en_US
dc.contributor.authorBhasin, Manojen_US
dc.contributor.authorKarumanchi, S. Ananthen_US
dc.contributor.authorKopcow, Hernan D.en_US
dc.date.accessioned2016-12-02T15:24:38Z
dc.date.issued2016en_US
dc.identifier.citationCavalli, R. C., A. S. Cerdeira, E. Pernicone, H. A. Korkes, S. D. Burke, A. Rajakumar, R. I. Thadhani, et al. 2016. “Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice.” PLoS ONE 11 (10): e0164353. doi:10.1371/journal.pone.0164353. http://dx.doi.org/10.1371/journal.pone.0164353.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626057
dc.description.abstractDecidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth restriction. Ex vivo manipulation of human peripheral blood NK (pNK) cells by a combination of hypoxia, TGFß-1 and 5-aza-2’-deoxycytidine yields cells with phenotypic and in vitro functional similarities to dNK cells, called idNK cells. Here, gene expression profiling shows that CD56Bright idNK cells derived ex vivo from human pNK cells, and to a lesser extent CD56Dim idNK cells, are enriched in the gene expression signature that distinguishes dNK cells from pNK cells. When injected into immunocompromised pregnant mice with elevated uterine artery resistance, idNK cells homed to the uterus and reduced the uterine artery resistance index, suggesting improved placental perfusion.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0164353en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063315/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectCardiovascular Anatomyen
dc.subjectBlood Vesselsen
dc.subjectArteriesen
dc.subjectMedicine and Health Sciencesen
dc.subjectGeneticsen
dc.subjectGene Expressionen
dc.subjectBiology and life sciencesen
dc.subjectCell biologyen
dc.subjectCellular typesen
dc.subjectAnimal cellsen
dc.subjectBlood cellsen
dc.subjectWhite blood cellsen
dc.subjectNK cellsen
dc.subjectImmune cellsen
dc.subjectImmunologyen
dc.subjectMedicine and health sciencesen
dc.subjectWomen's Healthen
dc.subjectMaternal Healthen
dc.subjectPregnancyen
dc.subjectObstetrics and Gynecologyen
dc.subjectReproductive Systemen
dc.subjectUterusen
dc.subjectModel Organismsen
dc.subjectAnimal Modelsen
dc.subjectMouse Modelsen
dc.subjectMolecular Biologyen
dc.subjectMolecular Biology Techniquesen
dc.subjectCloningen
dc.subjectComputational Biologyen
dc.subjectGenome Analysisen
dc.subjectTranscriptome Analysisen
dc.subjectGenomicsen
dc.titleInduced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorBurke, Suzanne D.en_US
dc.date.available2016-12-02T15:24:38Z
dc.identifier.doi10.1371/journal.pone.0164353*
dash.authorsorderedfalse
dash.contributor.affiliatedRoberts, Drucilla
dash.contributor.affiliatedThadhani, Ravi
dash.contributor.affiliatedBurke, Suzanne
dash.contributor.affiliatedKarumanchi, Subbian
dash.contributor.affiliatedBhasin, Manoj


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