Transforming Growth Factor-β1 as a Predictor for the Development of Hepatocellular Carcinoma: A Nested Case–Controlled Study
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CitationWatanabe, Yuko, Akira Iwamura, Yuichi J. Shimada, Kenji Wakai, Akiko Tamakoshi, and Hiroyasu Iso. 2016. “Transforming Growth Factor-β1 as a Predictor for the Development of Hepatocellular Carcinoma: A Nested Case–Controlled Study.” EBioMedicine 12 (1): 68-71. doi:10.1016/j.ebiom.2016.09.001. http://dx.doi.org/10.1016/j.ebiom.2016.09.001.
AbstractBackground: Transforming growth factor-β1 (TGF-β1) reportedly acts as a tumor suppressor in tumorigenesis. However, little is known as to how TGF-β1 concentrations change prior to the development of hepatocellular carcinoma (HCC) in humans. We examined the association between the serum TGF-β1 concentrations and death from HCC to determine whether the serum TGF-β1 can be a predictor of incident HCC. Methods: We conducted a nested case-controlled study of participants in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. We used a conditional logistic regression analysis to estimate the adjusted relative risks (aRRs) of death from HCC according to the serum TGF-β1 concentrations among 1940 participants including 83 patients with HCC and 1857 controls matched for age, sex, and hepatitis C virus (HCV)-antibody seropositivity. Findings: When serum TGF-β1 was modelled as a continuous variable, the aRR of death from HCC associated with a decrement of 7.9 ng/mL (one standard deviation) in the serum TGF-β1 concentrations was 2.3 (95% CI 1.7–3.0, P < 0.001) for all the subjects. The area under the receiver operating characteristic curve for the serum TGF-β1 concentrations was 0.78 (P < 0.05). Interpretation Our finding suggests that TGF-β1 serves as a predictor for HCC.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626059
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