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dc.contributor.authorChen, Xuguangen_US
dc.contributor.authorWang, Yunyueen_US
dc.contributor.authorNelson, Daviden_US
dc.contributor.authorTian, Saraen_US
dc.contributor.authorMulvey, Erinen_US
dc.contributor.authorPatel, Bhumien_US
dc.contributor.authorConti, Ilariaen_US
dc.contributor.authorJaen, Juanen_US
dc.contributor.authorRollins, Barrett J.en_US
dc.date.accessioned2016-12-02T15:24:43Z
dc.date.issued2016en_US
dc.identifier.citationChen, Xuguang, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, and Barrett J. Rollins. 2016. “CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice.” PLoS ONE 11 (11): e0165595. doi:10.1371/journal.pone.0165595. http://dx.doi.org/10.1371/journal.pone.0165595.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626071
dc.description.abstractChronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization. In contrast, disruption of Ccr2, which encodes CCL2’s sole signaling receptor, accelerated tumor development, shortened host survival, and mobilized EPCs. However, pharmacological inhibition of CCR2 phenocopied Ccl2 disruption rather than Ccr2 disruption, suggesting that the Ccr2-/- phenotype is a consequence of unanticipated alterations not linked to intact CCL2/CCR2 signaling. Consistent with this explanation, Ccr2-/- monocytes are more divergent from wild type monocytes than Ccl2-/- monocytes in their expression of genes involved in key developmental and functional pathways. Taken together, our data suggest a tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment and support the targeting of this chemokine/receptor pair in breast cancer.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0165595en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098736/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectCell Biologyen
dc.subjectCellular Typesen
dc.subjectAnimal Cellsen
dc.subjectBlood Cellsen
dc.subjectWhite Blood Cellsen
dc.subjectMonocytesen
dc.subjectImmune Cellsen
dc.subjectImmunologyen
dc.subjectMedicine and Health Sciencesen
dc.subjectModel Organismsen
dc.subjectAnimal Modelsen
dc.subjectMouse Modelsen
dc.subjectOrganismsen
dc.subjectAnimalsen
dc.subjectVertebratesen
dc.subjectAmniotesen
dc.subjectMammalsen
dc.subjectRodentsen
dc.subjectMiceen
dc.subjectOncologyen
dc.subjectCancers and Neoplasmsen
dc.subjectCarcinomasen
dc.subjectBreast Tumorsen
dc.subjectBreast Canceren
dc.subjectImmunologic Techniquesen
dc.subjectImmunoassaysen
dc.subjectEnzyme-Linked Immunoassaysen
dc.subjectCancer Treatmenten
dc.subjectPhysiologyen
dc.subjectImmune Physiologyen
dc.subjectBone Marrowen
dc.subjectImmune Systemen
dc.titleCCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorRollins, Barrett J.en_US
dc.date.available2016-12-02T15:24:43Z
dc.identifier.doi10.1371/journal.pone.0165595*
dash.contributor.affiliatedRollins, Barrett


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