Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
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Author
Alexandrov, Anton
Kim, Jaegil
Wala, Jeremiah
Pedamallu, Chandra Sekhar
Shukla, Sachet A.
Guo, Guangwu
Murray, Bradley A.
Imielinski, Marcin
Hu, Xin
Ling, Shiyun
Akbani, Rehan
Rosenberg, Mara
Cibulskis, Carrie
Ramachandran, Aruna
Collisson, Eric A.
Weinstein, John N.
Verhaak, Roel G. W.
Cherniack, Andrew D.
Artyomov, Maxim N.
Schreiber, Robert
Govindan, Ramaswamy
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https://doi.org/10.1038/ng.3564Metadata
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Campbell, J. D., A. Alexandrov, J. Kim, J. Wala, A. H. Berger, C. S. Pedamallu, S. A. Shukla, et al. 2016. “Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.” Nature genetics 48 (6): 607-616. doi:10.1038/ng.3564. http://dx.doi.org/10.1038/ng.3564.Abstract
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor/normal pairs. Recurrent alterations in lung SqCCs were more similar to other squamous carcinomas than to lung ADCs. Novel significantly mutated genes included PPP3CA, DOT1L, and FTSJD1 in lung ADC, RASA1 in lung SqCC, and KLF5, EP300, and CREBBP in both tumor types. Novel amplification peaks encompassed MIR21 in lung ADC, MIR205 in lung SqCC, and MAPK1 in both. Lung ADCs lacking receptor tyrosine kinase/Ras/Raf alterations revealed mutations in SOS1, VAV1, RASA1, and ARHGAP35. Regarding neoantigens, 47% of the lung ADC and 53% of the lung SqCC tumors had at least 5 predicted neoepitopes. While targeted therapies for lung ADC and lung SqCC are largely distinct, immunotherapies may aid in treatment for both subtypes.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884143/pdf/Terms of Use
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