Show simple item record

dc.contributor.authorAguilar, Carlos A.en_US
dc.contributor.authorPop, Ramonaen_US
dc.contributor.authorShcherbina, Annaen_US
dc.contributor.authorWatts, Alainen_US
dc.contributor.authorMatheny, Ronald W.en_US
dc.contributor.authorCacchiarelli, Davideen_US
dc.contributor.authorHan, Woojin M.en_US
dc.contributor.authorShin, Eunjungen_US
dc.contributor.authorNakhai, Shadi A.en_US
dc.contributor.authorJang, Young C.en_US
dc.contributor.authorCarrigan, Christopher T.en_US
dc.contributor.authorGifford, Casey A.en_US
dc.contributor.authorKottke, Melissa A.en_US
dc.contributor.authorCesana, Marcellaen_US
dc.contributor.authorLee, Jacksonen_US
dc.contributor.authorUrso, Maria L.en_US
dc.contributor.authorMeissner, Alexanderen_US
dc.date.accessioned2016-12-02T15:25:22Z
dc.date.issued2016en_US
dc.identifier.citationAguilar, C., R. Pop, A. Shcherbina, A. Watts, R. Matheny, D. Cacchiarelli, W. Han, et al. 2016. “Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma.” Stem Cell Reports 7 (5): 983-997. doi:10.1016/j.stemcr.2016.09.009. http://dx.doi.org/10.1016/j.stemcr.2016.09.009.en
dc.identifier.issn2213-6711en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626143
dc.description.abstractSummary Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration. However, a thorough understanding of the in vivo epigenomic and transcriptional mechanisms that control these reparative events is lacking. To address this, we monitored the in vivo dynamics of three histone modifications and coding and noncoding RNA expression throughout the regenerative process in a mouse model of traumatic muscle injury. We first illustrate how both coding and noncoding RNAs in tissues and sorted satellite cells are modified and regulated during various stages after trauma. Next, we use chromatin immunoprecipitation followed by sequencing to evaluate the chromatin state of cis-regulatory elements (promoters and enhancers) and view how these elements evolve and influence various muscle repair and regeneration transcriptional programs. These results provide a comprehensive view of the central factors that regulate muscle regeneration and underscore the multiple levels through which both transcriptional and epigenetic patterns are regulated to enact appropriate repair and regeneration.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.stemcr.2016.09.009en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106515/pdf/en
dash.licenseLAAen_US
dc.titleTranscriptional and Chromatin Dynamics of Muscle Regeneration after Severe Traumaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalStem Cell Reportsen
dash.depositing.authorPop, Ramonaen_US
dc.date.available2016-12-02T15:25:22Z
dc.identifier.doi10.1016/j.stemcr.2016.09.009*
dash.authorsorderedfalse
dash.contributor.affiliatedCesana, Marcella
dash.contributor.affiliatedPop, Ramona
dash.contributor.affiliatedCacchiarelli, Davide
dash.contributor.affiliatedMeissner, Alexander


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record